Method for treating sepsis and related diseases
AssigneeThe Regents of the University of Colorado, a body corporate
InventorLeland Shapiro
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Abstract
The present disclosure provides a method for treating sepsis caused by a microorganism infection. The disclosure also relates to a method for identifying and discovering compounds useful in treating sepsis as well as a method for determining appropriate approaches for treating sepsis. In particular, the methods of the disclosure are based on the discovery by the present inventor that sepsis is caused by exotoxin(s) of microorganism or by constitutive proteins that function as exotoxins as in the case of viruses.
Claims20
A method for treating a subject for a clinical condition associated with a microorganism infection, said method comprising administering to a subject in need of such a treatment a therapeutically effective amount of a therapeutic agent capable of reducing the effect of an exotoxin or exotoxin-functioning constitutive molecule associated with said microorganism, thereby treating said subject.
A method for treating a disease or a clinical condition caused by a microorganism infection in a patient, said method comprising:
- identifying the microorganism causing the disease or the clinical condition in the patient;
- and
- administering to the patient a therapeutically effective amount of a therapeutic agent capable of reducing the effect of one or more exotoxins produced by said microorganism, thereby treating the disease or the clinical conditions caused by the microorganism infection in the patient.
A method for producing a therapeutic agent for treating a microorganism infection in a subject, said method comprising:
- identifying one or more exotoxin(s) associated with the microorganism;
- and
- producing a therapeutic agent that inhibits activity of said exotoxin(s).
Dependencies are inferred from the claim text.