Variant anti-viral polypeptides
AssigneeInternational N&H Denmark Aps
InventorsCristina BONGIORNI, Mai DU, David A. ESTELL, Keith FROGUE, Amy Deming LIU, Darshana KADEKAR
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Abstract
Provided herein, inter alia, are variant lectin anti-viral polypeptides as well as compositions and methods for expressing and using the same for the treatment and prevention of viral disease in animals.
Claims68
A non-naturally occurring variant lectin polypeptide or functional fragment thereof comprising an amino acid sequence at least about 60% identical to SEQ ID NO:8 or SEQ ID NO:18 comprising one or more substitutions at positions 10, 38, 53, 54, and 78.
The polypeptide of claim 27, wherein the substitution at position 10 is X10N or D;
- the substitution at position 38 is X38Q;
- and the substitution at position 53 is X53E, L, or K.
The polypeptide of claim 28, wherein the substitution at position 10 is SION or D;
- the substitution at position 38 is H38Q;
- and the substitution at position 53 is G53E, L, or K.
A polypeptide dimer comprising two polypeptides or functional fragments thereof comprising an amino acid sequence at least about 60% identical to SEQ ID NO:8 or SEQ ID NO:18.
Dependencies are inferred from the claim text.