US 2026/0092078 A1Published application

Stat6 degraders and uses thereof

AssigneeKymera Therapeutics, Inc.

InventorsBin Yang, Bruce C. Follows, Huijun Dong, Lewis Dale Pennington, Eamon Comer, Melissa Ford

Life of this patent

Estimating the term…

The present invention provides compounds, compositions thereof, and methods of using the same.

Dependent claims

A compound of formula I:

or a pharmaceutically acceptable salt thereof, wherein:
SBM is a STAT6 binding moiety capable of binding to STAT6 protein;
L is a bivalent moiety that connects SBM to DIM;
and
DIM is a degradation inducing moiety selected from an E3 ubiquitin ligase binding moiety (LBM), lysine mimetic, and hydrogen.

2 more elements

Dependencies are inferred from the claim text.

C07D 417/14
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms,…
C07F 9/655354
The sulfur atom being part of a five-membered ring: condensed with carbocyclic rings or carbocyclic ring systems
A61K 31/662
Phosphorus compounds: phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
A61K 31/67
Phosphorus compounds: having sulfur as a ring hetero atom

From the US filing history. Foreign family members aren’t listed.

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