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US 2026/0092060 A1Published application
Isotopically enriched analogs of 2-bromo-lsd, lsd, ald-52, and 1p-lsd
OwnerMatthew DUNCTON, Samuel CLARKinventors
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Abstract
Disclosed herein are isotopically enriched compounds of 2-bromolysergic acid diethylamide, LSD, ALD-52, and 1P-LSD, as well as methods for their use in treating neurologic and brain disorders.
Claims30
A compound of Formula (A)
- or a pharmaceutically acceptable salt thereof, wherein:
- R1, R2, and R3 are methyl;
- Ra is hydrogen, deuterium, tritium, acetyl, or 1-propionyl;
- Rb is hydrogen, deuterium, tritium, or bromo;
- Y1, Y2, Y3, Y4, Y5, Y6, Y7, Y8, Y9, Y10, Y11, Y14, Y15, and Y16 are independently selected from hydrogen, deuterium, and tritium;
- and
- at least one of R1, R2, R3, Ra, Rb, Y1, Y2, Y3, Y4, Y5, Y6, Y7, Y8, Y9, Y10, Y11, Y14, Y15, and Y16 is or comprises deuterium or tritium.
4 more elements
3-5. (canceled)
8-10. (canceled)
14-16. (canceled)
19-21. (canceled)
25-27. (canceled)
31-33. (canceled)
36-45. (canceled)
A compound having any one of the structures shown in Table 1, or a pharmaceutically acceptable salt thereof.
47-48. (canceled)
50-51. (canceled)
53-60. (canceled)
Dependencies are inferred from the claim text.