Crystalline salt forms of n-((1-(2-(tert-butylamino)-2-oxoethyl)piperidin-4-yl) methyl)-3-chloro-5-fluorobenzamide and methods of use thereof
AssigneePraxis Precision Medicines, Inc.
InventorsDavid T. Jonaitis, Lisa McCracken
Life of this patent
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Abstract
Described herein, in part, are crystalline and salt forms of N-((1-(2-(tert-butylamino)-2-oxoethyl)piperidin-4-yl)methyl)-3-chloro-5-fluorobenzamide useful for preventing and/or treating a disease or condition relating to aberrant function of a T-type calcium channel, such as epilepsy and epilepsy syndromes (e.g., absence seizures, juvenile myoclonic epilepsy, or a genetic epilepsy), tremor (e.g., essential tremor), and psychiatric disorder (e.g., mood disorders (e.g., major depressive disorder)).
Claims45
A salt of Compound 1, wherein Compound 1 is represented by the following structural formula:
- and wherein the salt is selected from the group consisting of acetate salt, adipate salt, alginate salt, ascorbate salt, asparatate salt, besylate salt, benzoate salt, citrate salt, cyclamate salt, edisylate salt, esylate salt, isethionate salt, fumarate salt, gentisate salt, gluconate salt, glucuronate salt, glutamate salt, glutarate salt, ketoglutarate salt, glycolate salt, hippurate salt, lactobionate salt, maleate salt, malate salt, malonate salt, mesylate salt, napadisylate salt, napsylate salt, oleate salt, oroate salt, oxalate salt, pamoate salt, phosphate salt, sebacate salt, succinate salt and tartrate salt.
A crystalline form of a salt of Compound 1, wherein Compound 1 is represented by the following structural formula:
- and wherein the salt is selected from the group consisting of adipate salt, besylate salt, cyclamate salt, edisylate salt, esylate salt, fumarate salt, glutarate salt, glycolate salt, inappendiculate salt, napsylate salt, orotate salt, oxalate salt, maleate salt, malonate salt, mesylate salt, pamoate salt, phosphate salt, and sebacate salt.
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Dependencies are inferred from the claim text.