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US 2026/0091368 A1Published application
System and method of applied radial technology chromatography
Assigneeemp Biotech GmbH
InventorsAlistair J. HURST, Derek W.K. LEVISON
Life of this patent
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Abstract
A system and method of applied radial technology chromatography using a plurality of beads is disclosed, with each bead comprising one or more pores therein having a diameter of about 250 Å to about 5000 Å, and each bead having an average radius between about 100 μm to about 250 μm. Also disclosed are processes for selecting beads for use in a radial flow chromatography column, and for purifying an unclarified feed stream using a radial flow chromatography column.
Claims16
A radial flow chromatography column comprising:
- a plurality of beads, with each bead comprising one or more pores therein, and interstitial channels formed between the beads,
- wherein each pore has a diameter of about 250 Å to about 5000 Å,
- wherein at least about 80% of the plurality of beads have a diameter of about 200 μm to about 500 μm and
- wherein the beads have an average radius R of about 100 μm to about 250 μm.
1 more element
A process for selecting beads for use in a radial flow chromatography column comprising:
- a) identifying a narrow desirable bead radius R range based on the components present in the feed stream;
- b) removing beads of a defined radius r, which are outside of the desirable bead range;
- and c) defining the percentage of bead radius R within the desirable bead range.
Dependencies are inferred from the claim text.