Method for manufacturing product, hollow fiber membrane filter, and apparatus for manufacturing product

A hollow fiber membrane filter used for a method for manufacturing a product obtained by culturing cells in a culture solution accommodated in a tank having a capacity of 100 L or more, the hollow fiber membrane filter comprising:

• a hollow fiber membrane having a primary flow passage extending in a longitudinal direction inside the hollow fiber membrane;
• and
• a housing accommodating a plurality of the hollow fiber membranes,
• wherein a length L of the hollow fiber membrane and an inner diameter d of the hollow fiber membrane each satisfy L≤290 mm and d≥1 mm, and
• a relationship between the length L and the inner diameter d satisfies L/d≤290.

An apparatus for manufacturing a product used for a method for manufacturing a product obtained by culturing cells in a culture solution, the apparatus comprising:

• a tank having a capacity of 100 L or more, the tank accommodating the culture solution;
• a hollow fiber membrane filter which has a hollow fiber membrane having a primary flow passage extending in a longitudinal direction inside the hollow fiber membrane and a housing accommodating a plurality of the hollow fiber membranes, in which a length L of the hollow fiber membrane and an inner diameter d of the hollow fiber membrane each satisfy L≤290 mm and d≥1 mm, and a relationship between the length L and the inner diameter d satisfies L/d≤290;
• a first pump which feeds the culture solution to the primary flow passage of the hollow fiber membrane filter;
• and
• a second pump which feeds, to a product recovery part, a permeated liquid passing through a secondary flow passage of the hollow fiber membrane filter in a case where the culture solution is fed along the primary flow passage of the hollow fiber membrane filter.