Treatment of epilepsy
AssigneeModulight Bio Ltd.
InventorsYotam ELDAR, Yoav KFIR
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Abstract
Methods of treating epilepsy are provided. Accordingly, there is provided a method of treating epilepsy in a subject in need thereof, the method comprising: (a) administering into a thalamus nucleus of the subject a therapeutically effective amount of a polynucleotide encoding a bistable type II opsin attached to a heterologous ER export signal and/or membrane trafficking signal which enables trafficking of said bistable type II opsin to axonal presynaptic terminals; and (b) exposing a neural region of said subject to light in a wavelength that activates said bistable type II opsin, wherein said neural region comprises a cell body and/or an axon of said thalamus nucleus.
Claims20
A method of treating epilepsy in a subject in need thereof, the method comprising:
- (a) administering into a thalamus nucleus of the subject a therapeutically effective amount of a polynucleotide encoding a bistable type II opsin attached to a heterologous ER export signal and/or membrane trafficking signal which enables trafficking of said bistable type II opsin to axonal presynaptic terminals;
- and
- (b) exposing a neural region of said subject to light in a wavelength that activates said bistable type II opsin, wherein said neural region comprises a cell body and/or an axon of said thalamus nucleus,
- thereby treating epilepsy in the subject.
A method of treating epilepsy in a subject in need thereof having been administered into a thalamus nucleus a therapeutically effective amount of a polynucleotide encoding a bistable type II opsin attached to a heterologous ER export signal and/or membrane trafficking signal which enables trafficking of said bistable type II opsin to axonal presynaptic terminals, the method comprising exposing a neural region of said subject to light in a wavelength that activates said bistable type II opsin, wherein said neural region comprises a cell body and/or an axon of said thalamus nucleus, thereby treating epilepsy in the subject.
Dependencies are inferred from the claim text.