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US 2026/0091008 A1Published application
Double targeted constructs to affect tumor kill
AssigneeCornell University
InventorsJohn W. Babich, James M. Kelly, Alejandro Amor-Coarasa, Shashikanth Ponnala
Life of this patent
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Abstract
The present technology is directed to compounds, compositions, medicaments, and methods related to the treatment of cancers expressing PSMA. The compounds are of Formulas I & II or pharmaceutically acceptable salts thereof. The present technology is especially well-suited for use in treating prostate cancer.
Claims21
-20. (canceled)
A compound of Formula II
- or a pharmaceutically acceptable salt thereof, wherein
- X2 is 124I, 125I, 131I, 211At, or Sn(R8)3;
- R5, R6, and R7 are each independently H, methyl, benzyl, 4-methoxybenzyl, or tert-butyl;
- R8 is independently at each occurrence an alkyl group;
- W1 is a bond or —NH-alkylene-;
- and
- p is 0, 1, 2, or 3.
4 more elements
Dependencies are inferred from the claim text.