Cardiac biopsy devices with sensing and associated methods

A device for collecting a biopsy sample, the device comprising:

• an elongate shaft comprising a proximal end and a distal end, wherein the distal end is configured to be introduced into a heart of a patient and positioned proximate to cardiac tissue of the heart;
• a helical element at the distal end of the elongate shaft, wherein the helical element is configured to be advanced into the cardiac tissue;
• at least one sensor configured to generate sensor data indicative of a characteristic of the cardiac tissue;
• and
• a controller comprising one or more processors and a memory storing instructions that, when executed by the one or more processors, cause the controller to perform operations comprising:
• receiving the sensor data from the at least one sensor,
• determining whether the cardiac tissue comprises pathological tissue based on the sensor data,
• if the cardiac tissue comprises pathological tissue, instructing a user to collect a sample of the pathological tissue using the helical element, and
• if the cardiac tissue does not comprise pathological tissue, instructing the user to reposition the distal end of the elongate shaft.