# US 2026/0090723 A1 · Disposable fiber-optic sensor device for assessing tissue biomechanical properties

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- Number: US 2026/0090723 A1
- Document ID: US20260090723A1
- Status: Published application
- Kind: A1
- Application number: 19/347,485
- Filed: 2025-10-01
- Published: 2026-04-02
- Earliest claimed: 2024-10-01
- Assignees: Washington University
- Applicants: Washington University
- Inventors: Song Hu; Jingwei Ling; Shuo Yang
- Web page: https://patentgrep.com/patent/US20260090723A1

## CPC

- A61B 5/0084: {for introduction into the body, e.g. by catheters (A61B5/1459 takes precedence)}
- A61B 5/0051: {by applying vibrations}
- A61B 5/0053: {by applying pressure, e.g. compression, indentation, palpation, grasping, gauging}
- A61B 5/0075: {by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy (A61B5/0071 takes precedence)}
- A61B 5/442: {Evaluating skin mechanical properties, e.g. elasticity, hardness, texture, wrinkle assessment}
- G01J 3/26: using multiple reflection, e.g. Fabry-Perot interferometer, variable interference filters
- A61B 2560/063: Devices specially adapted for delivering implantable medical measuring apparatus
- A61B 2562/0233: Special features of optical sensors or probes classified in A61B5/00
- A61B 2562/164: the sensor is mounted in or on a conformable substrate or carrier
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G01J: MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY (light sources F21, H01J, H01K, H05B; investigating properties of materials by optical means G01N)

## Abstract

Among the various aspects of the present disclosure is the provision of a disposable fiber optic sensor device for assessing tissue biomechanical properties. Disclosed herein is a fiber-optic sensor device that includes an optical fiber with a fiber tip, a displacement driver, and an interrogation system. A method to measure a biomechanical property of a tissue is also disclosed, which includes using a fiber optic sensor device to compress the targeted tissue with predefined displacement and frequency, where the counterforce deforms the soft cavity and, in turn, modulates the interference pattern is also disclosed.

## Claims

### Claim 1

A fiber-optic biomechanical sensing system, the system comprising:
a. a biomechanical sensor comprising:
i. an optical fiber comprising opposed proximal and distal ends; and
ii. a deformable Fabry-Perot interferometer optically coupled to the distal end of the optic fiber;
b. a light source optically coupled to the biomechanical sensor at the proximal end of the optic fiber;
c. a vibrational indentation module mechanically coupled to the biomechanical sensor, the vibrational indentation module configured to periodically advance and retract the biomechanical sensor along a proximal-distal axis at a predetermined frequency and displacement; and
d. a spectrometer optically coupled to the fiber optic of the biomechanical sensor, the spectrometer configured to receive a plurality of optical signals from the deformable Fabry-Perot interferometer;
wherein the optical signals encode interference patterns generated by the deformable Fabry-Perot interferometer in response to the periodic displacements of the biomechanical sensor by the vibrational indentation module.

### Claim 2 (depends on 1)

The system of claim 1, wherein the optical fiber is a polymer-coated glass optical fiber.

### Claim 3 (depends on 1)

The system of claim 1, wherein the Fabry-Perot interferometer comprises:
a. a deformable cavity comprising a proximal surface optically coupled to the distal end of the fiber optic and a distal surface opposite the proximal surface;
b. a first reflective coating covering at least a portion of the proximal surface, the first reflective coating configured to reflect a first portion of light from the light source at the distal end of the optic fiber and further configured to transmit a second portion of light from the light source to the distal surface of the deformable cavity; and
c. a second reflective coating covering at least a portion of the distal surface of the deformable cavity, the second reflective coating configured to reflect the second portion of light back through the first reflective coating and optic fiber;
wherein the reflected first and second portions of light form an interference pattern propagating through the optic fiber to the spectrometer.

### Claim 4 (depends on 1)

The system of claim 1, wherein the deformable cavity comprises a soft and transparent material selected from polydimethylsiloxane (PDMS), a hydrogel, and an optical adhesive.

### Claim 5 (depends on 1)

The system of claim 1, wherein the first and second reflective coatings comprise at least one dielectric material.

### Claim 6 (depends on 5)

The system of claim 5, wherein the dielectric materials of the first and second reflective coatings are selected independently from titanium dioxide (TiO2), zinc oxide (ZnO), and any combination thereof.

### Claim 7 (depends on 5)

The system of claim 5, wherein the first and second reflective coatings comprise thin dielectric coatings formed using a sol-gel method to increase light reflectivity.

### Claim 8 (depends on 1)

The system of claim 1, wherein the light source comprises a broadband light source selected from a light-emitting diode (LED), a superluminescent diode (SLED), and a lamp.

### Claim 9 (depends on 1)

The system of claim 1, wherein the interference patterns generated by the deformable Fabry-Perot interferometer are modulated by changes in a cavity thickness between the proximal and distal surfaces of the deformable cavity induced by compressions associated with the periodic displacements of the biomechanical sensor by the vibrational indentation module.

### Claim 10 (depends on 1)

The system of claim 1, wherein the biomechanical sensor is disposable and autoclavable for sterilization to facilitate clinical translation.

### Claim 11 (depends on 1)

The system of claim 1, wherein the biomechanical sensor is mass-producible.

### Claim 12 (depends on 1)

The system of claim 1, wherein the vibrational indentation module comprises a piezo actuator operatively coupled to a controller, the controller comprising a voltage modulator.

### Claim 13 (depends on 12)

The system of claim 12, wherein the voltage modulator is configured to produce a modulated voltage at a predetermined frequency or shape to actuate the periodic displacements of the piezo actuator.

### Claim 14 (depends on 1)

The system of claim 1, wherein the spectrometer is a high-speed spectrometer.

### Claim 15 (depends on 1)

The system of claim 1, wherein the biomechanical sensor is further configured to be deployed through a standard 25-gauge injection needle.

### Claim 16 (depends on 1)

The system of claim 1, wherein the biomechanical sensor further comprises a cross-sectional diameter of about 140 μm.

### Claim 17

A method to measure at least one biomechanical property of a tissue, the method comprising:
a. providing a fiber-optic biomechanical sensing system, the system comprising:
i. a biomechanical sensor comprising:
1. a fiber optic comprising opposed proximal and distal ends; and
2. a deformable Fabry-Perot interferometer optically coupled to the distal end of the optic fiber;
ii. a light source optically coupled to the biomechanical sensor at the proximal end of the optic fiber;
iii. a vibrational indentation module mechanically coupled to the biomechanical sensor, the vibrational indentation module configured to periodically advance and retract the biomechanical sensor along a proximal-distal axis at a predetermined frequency and displacement; and
iv. a spectrometer optically coupled to the fiber optic of the biomechanical sensor, the spectrometer configured to receive a plurality of optical signals from the deformable Fabry-Perot interferometer, wherein the optical signals encode interference patterns generated by the deformable Fabry-Perot interferometer in response to the periodic displacements of the biomechanical sensor by the vibrational indentation module;
b. positioning the deformable Fabry-Perot interferometer of the biomechanical sensor against the tissue;
c. periodically advancing and retracting the biomechanical sensor along a proximal-distal axis at a predetermined frequency and displacement while delivering light from the light source to generate a series of interference patterns;
d. detecting the series of interference patterns at the spectrometer; and
e. transforming the series of interference patterns into the at least one biomechanical property of the tissue.

### Claim 18 (depends on 17)

The method of claim 17, wherein the at least one biomechanical property is selected from stiffness, viscosity, and any combination thereof.

### Claim 19 (depends on 17)

The method of claim 17, wherein the at least one biomechanical property is recorded in real-time.

### Claim 20 (depends on 17)

The method of any one of claim 17, wherein positioning the deformable Fabry-Perot interferometer of the biomechanical sensor against the tissue comprises deploying the biomechanical sensor through a standard injection needle.