N-(benzhydryl)cycloalkylcarboxamide derivatives as inhibitors of glycogen synthase 1 (gys1) and methods of use thereof

A compound of formula (I):

• or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein:
• Y1 and Y2 are each CH, or
• one of Y1 and Y2 is N and the other of Y1 and Y2 is CH;
• X1 and X2 are each independently H or halo;
• R3 and R4 are each —CH3, or
• R3 and R4 are taken, together with the atoms to which they are attached, to form cyclopropyl or cyclobutyl;
• either
• (1) L is absent;
• and
• Q1 is:
• (i) C6-20aryl, wherein the C6-20aryl of Q1 is optionally substituted with one or more —OH, —NH2, halo, C1-6alkyl, C1-6alkoxy, C3-10cycloalkyl, 5-20 membered heteroaryl, —NH—C(O)—NH2, —NH—C(O)—NH(C1-6alkyl), —NH—C(O)—C1-6alkyl, —NH—C(O)—C3-10cycloalkyl, —NH—C(O)-(3-15 membered heterocyclyl), —NH—C(═N—CN)—NH2, —NH—S(O)2—C1-6alkyl, —NH(C1-6alkyl), —NH-(3-15 membered heterocyclyl), or —NH-(5-20 membered heteroaryl), wherein
• the 3-15 membered heterocyclyl of the —NH—C(O)-(3-15 membered heterocyclyl) is optionally substituted with one or more —C(O)—C1-6alkyl or C1-6alkyl, wherein the C1-6alkyl is optionally substituted with one or more halo, C1-6alkoxy, or C3-10cycloalkyl, and
• the 3-15 membered heterocyclyl of the —NH-(3-15 membered heterocyclyl) is optionally substituted with one or more oxo or C1-6alkyl, or
• (ii) 3-15 membered heterocyclyl, wherein the 3-15 membered heterocyclyl of Q1 is optionally substituted with one or more oxo, or
• (iii) 5-20 membered heteroaryl, wherein the 5-20 membered heteroaryl of Q1 comprises at least one annular N atom and is optionally substituted with one or more —NH2, halo, C1-6alkyl, or C3-10cycloalkyl;
• or
• (2) L is —CH2—;
• and
• Q1 is C3-10cycloalkyl;
• m is 0 or 1;
• n is 0 or 1;
• R1 is H, halo, —CN, —C(O)—NH2, —C(O)—NH(CN), —C(O)—NH(C1-6alkyl), —NH—C(O)—NH2, or —NH—C(O)—C1-6alkyl, wherein
• the C1-6alkyl of the —C(O)—NH(C1-6alkyl) of R1 is optionally substituted with one or more —C(O)—C1-6alkoxy, and
• the C1-6alkyl of the —NH—C(O)—C1-6alkyl of R1 is optionally substituted with one or more —NH—C(O)—C1-6alkyl or —C(O)—NH2;
• and
• R2 is H, halo, or —OH.