Polymer sequencing apparatus, methods of fabrication and use
AssigneeArmonica Technologies, Inc.
InventorsVictor Esch, Steve Brueck, Xin Jin, Hui Xia
Life of this patent
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Abstract
The systems disclosed herein may a nanoscale chip. The chip includes a nanochannel with two nanoscale transverse dimensions and a SERS enhancement structure therein, alignment marks for enabling positioning of a laser excitation beam onto the enhancement structure, and a structural element for controlling the positioning of a polymer within the nanofluidic chip relative to the enhancement structure. The system may further comprise a reader for analyzing polymers on the chip. The disclosure also relates to methods of fabricating the chip and sequencing a polymer using the chip and reader.
Claims22
1-32. (canceled)
A fabrication method for a nanofluidic chip for sequencing polymers, the method comprising:
- depositing a dielectric film on a substrate;
- forming within the dielectric film at least one alignment mark, a channel and a pocket within the channel;
- forming an enhancement structure in the pocket;
- and
- covering the channel with a coverslip.
53-70. (canceled)
Dependencies are inferred from the claim text.