Methods and products for improving sperm quality
AssigneeThe University of Adelaide
InventorsRebecca Louise Robker, Macarena Bermudez Gonzalez
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Abstract
Disclosed are methods and products for improving the quality of sperm, methods for treating subjects to improve sperm quality or improve fertility, and use of sperm with improved quality in assisted reproductive technologies, including exposing the sperm to BGP-15 and/or a derivative thereof, such as BGP-15, propanolol, bimoclomol, arimoclomal, NG94, iroxanadine, and/or a pharmaceutically acceptable derivative, prodrug, solvate, salt, tautomer, stereoisomer, and/or racemate thereof.
Claims43
A method of improving quality of sperm, the method comprising exposing the sperm to BGP-15 and/or a derivative thereof and thereby improving the quality of the sperm.
A method of treating a subject to improve sperm quality, the method comprising administering to the subject to an effective amount of BGP-15 and/or a derivative thereof and thereby improving sperm quality in the subject.
A method of treating reduced sperm quality in a subject, the method comprising administering to the subject an effective amount of BGP-15 and/or a derivative thereof and thereby treating the subject.
Use of BGP-15 and/or a derivative thereof in a composition for improving sperm quality.
A pharmaceutical composition for improving sperm quality, the composition comprising an effective amount of BGP-15 and/or a derivative thereof.
A method of improving developmental competence of an embryo produced by a sperm fertilising an oocyte, the method comprising exposing the sperm to BGP-15 and/or a derivative thereof and thereby improving the developmental competence of the embryo.
A method of assisted reproduction using sperm, the method comprising exposing the sperm to BGP-15 and/or a derivative thereof and using the sperm exposed to the BGP-15 and/or a derivative thereof in the method of assisted reproduction.
An in vitro fertilization method, the method comprising:
- exposing sperm in vitro to BGP-15 and/or a derivative thereof;
- and fertilizing an oocyte with the sperm exposed to the BGP-15 and/or a derivative thereof.
A kit or product for improving quality of sperm, the kit or product comprising BGP-15 and/or a derivative thereof for exposure to the sperm.
A kit or product for use in an assisted reproduction method, the kit or product comprising BGP-15 and/or a derivative thereof for exposure to sperm.
An in vitro fertilization medium for sperm, the medium comprising BGP-15 and/or a derivative thereof.
A sperm preparation medium, the medium comprising BGP-15 and/or a derivative thereof.
A method of freezing sperm, the method comprising exposing the sperm to BGP-15 and/or a derivative thereof at one more of before, during and/or after freezing of the sperm.
A sperm freezing medium, the medium comprising BGP-15 and/or a derivative thereof.
A method of screening for an agent to improve sperm quality, the method comprising determining the ability of a derivative of BGP-15 to improve quality of sperm and identifying the derivative as an agent to improve sperm quality.
Dependencies are inferred from the claim text.