# US 2026/0083589 A1 · Device for injecting a substance into an interlayer of a body tissue or organ

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2026/0083589 A1
- Document ID: US20260083589A1
- Status: Published application
- Kind: A1
- Application number: 19/404,225
- Filed: 2025-12-01
- Published: 2026-03-26
- Earliest claimed: 2018-04-19
- Assignees: Everads Therapy Ltd.
- Applicants: Everads Therapy Ltd.
- Inventors: Keren Mano Tamir; Hagay Drori
- Web page: https://patentgrep.com/patent/US20260083589A1

## CPC

- A61F 9/00736: {Instruments for removal of intra-ocular material or intra-ocular injection, e.g. cataract instruments (A61F9/008 takes precedence)}
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)

## Abstract

A method is described for performing suprachoroidal buckling in an eye of a subject. A sharp needle distal tip of a device is used to partially penetrate at a penetration point into a sclera of the eye, not completely through the sclera. An elongated tissue separator is moved distally within the needle lumen such that the separator distal tip moves distally to the sharp needle distal tip and penetrates into a choroid of the eye and forms a suprachoroidal passage in the choroid. The device is used to inject a fluid into the suprachoroidal passage. The fluid includes a therapeutic composition including viscous agents to achieve suprachoroidal buckling, including a short term buckling effect or a long term buckling effect.

## Claims

### Claim 1

A method for performing suprachoroidal buckling in an eye of a subject, the method comprising:
providing a device for injection into an interlayer of an organ of the subject, the device comprising: a needle comprising a needle lumen extending between a needle proximal end and a needle distal end, said needle distal end terminating in a sharp needle distal tip; an elongated tissue separator having a separator distal tip, at least a portion of said elongated tissue separator being shiftable in said needle lumen;
and an actuator configured to shift said elongated tissue separator in said needle lumen between a first position, wherein said separator distal tip is positioned proximally to said needle distal tip, and a second position, wherein said separator distal tip is positioned a first predetermined distance distally from said needle distal tip;
using said sharp needle distal tip to partially penetrate at a penetration point into a sclera of the eye, not completely through the sclera;
moving said elongated tissue separator distally within said needle lumen such that said separator distal tip moves distally to said sharp needle distal tip and penetrates into a choroid of the eye and forms a suprachoroidal passage in the choroid; and
using the device to inject a fluid into the suprachoroidal passage, the fluid comprising a therapeutic composition comprising viscous agents to achieve suprachoroidal buckling, comprising a short term buckling effect or a long term buckling effect.

### Claim 2 (depends on 1)

The method according to claim 1, wherein said penetration point is located at a selected distance from a limbus of the eye.

### Claim 3 (depends on 1)

The method according to claim 1, wherein a location of said penetration point is adjusted relative to a location of a retinal tear.

### Claim 4 (depends on 1)

The method according to claim 1, wherein injection of said fluid creates a dome-shaped choroidal indentation.

### Claim 5 (depends on 4)

The method according to claim 4, wherein said dome-shaped choroidal indentation is smooth.

### Claim 6 (depends on 4)

The method according to claim 4, wherein said dome-shaped choroidal indentation provides stable retinal re-apposition.

### Claim 7 (depends on 1)

The method according to claim 1, wherein said suprachoroidal buckling is used to treat Rhegmatogenous Retinal Detachment (RRD).

### Claim 8 (depends on 1)

The method according to claim 1, wherein said suprachoroidal buckling is used to treat a peripheral retinal break or tear.

### Claim 9 (depends on 1)

The method according to claim 1, wherein said suprachoroidal buckling is used to treat a phakic retinal detachment.

### Claim 10 (depends on 1)

The method according to claim 1, wherein said suprachoroidal buckling is used to treat Myopic Traction Maculopathy (MTM).

### Claim 11 (depends on 1)

The method according to claim 1, wherein said suprachoroidal buckling is used to treat Myopic Macular Hole Detachment.

### Claim 12 (depends on 1)

The method according to claim 1, wherein said suprachoroidal buckling is combined with Pars Plana Vitrectomy (PPV).

### Claim 13 (depends on 1)

The method according to claim 1, wherein said suprachoroidal buckling is used to provide support for multiple or extended retinal tears.

### Claim 14 (depends on 1)

The method according to claim 1, wherein said suprachoroidal buckling is combined with a scleral buckle.