Back to results
US 2026/0078376 A1Published application
Oligonucleotides for the treatment of breast cancer
AssigneeCore Biotherapeutics, Inc.
InventorsMichael KLUKINOV, David C. YEOMANS, Julien MAMET
Life of this patent
Estimating the term…
Abstract
Provided are therapeutic agents such as double-stranded nucleic acids, termed oligonucleotide decoys, pharmaceutical compositions comprising the same, and related methods of modulating breast cancer signaling, for instance, to treat breast cancer.
Claims36
An oligonucleotide decoy, comprising:
- at least two transcription factor binding sites, wherein each transcription factor binding site binds to a transcription factor selected from the group consisting of:
- BCL11A, CxxC domain-containing proteins (e.g., CXXC5), E2F (e.g., E2F5, E2F3), FOX (e.g., FOXC1, FOXM1), GTF2IRD1, HMGA1, HOXB5, LYL1, MAF (e.g., c-MAF, MAF-k), MAX, MYC, NFIL3, TCF (e.g., TCF3, TCF4, TCF7L1), TGIF2, XBP1, YBX1, YY1, ZEB2 and closely related factors.
A method for modulating breast cancer signaling in a cell, comprising:
- administering to the cell a therapeutically effective amount of a therapeutic agent, wherein the therapeutic agent inhibits binding of a transcription factor to its transcription factor binding site, wherein the transcription factor is selected from the group consisting of BCL11A, CxxC domain-containing proteins (e.g., CXXC5), E2F (e.g., E2F5, E2F3), FOX (e.g. FOXC1, FOXM1), GTF2IRD1, HMGA1, HOXB5, LYL1, MAF (e.g. c-MAF, MAF-k), MAX, MYC, NFIL3, TCF (e.g., TCF3, TCF4, TCF7L1), TGIF2, XBP1, YBX1, YY1, ZEB2 and closely related factors.
A method for treating breast cancer in a subject in need thereof, comprising:
- administering to the subject a therapeutically effective amount of a therapeutic agent, wherein the therapeutic agent inhibits binding of a transcription factor to its transcription binding site, wherein the transcription factor is selected from the group consisting of BCL11A, CxxC domain-containing proteins (e.g., CXXC5), E2F (e.g., E2F5, E2F3), FOX (e.g. FOXC1, FOXM1), GTF2IRD1, HMGA1, HOXB5, LYL1, MAF (e.g. c-MAF, MAF-k), MAX, MYC, NFIL3, TCF (e.g., TCF3, TCF4, TCF7L1), TGIF2, XBP1, YBX1, YY1, ZEB2 and closely related factors.
Dependencies are inferred from the claim text.