Treating chronic inflammation and cancer by macrophage polarization
AssigneeGeorgia State University Research Foundation, Inc.
InventorsZhi-Ren LIU, Guangda PENG
Life of this patent
Estimating the term…
Abstract
A method for treating a disease or disorder includes administering to a subject an effective amount of an agent that promotes the polarization of macrophages. The macrophages selectively repolarize their phenotype in the microenvironment. The agent can be PKM2 or mutant thereof. Further, wherein administration of the agent reduces inflammation in the subject.
Claims23
A method for treating a disease or disorder, comprising administering to a subject an effective amount of an agent that promotes the polarization of macrophages, wherein the macrophages selectively repolarize their phenotype in the microenvironment.
A method for treating a disease associated with inflammation in a subject, comprising administering to the subject an effective amount of a composition having a pyruvate kinase isoform M2 (PKM2) antibody or binding molecules, wherein the effective amount induces M1 pro-inflammatory macrophage polarization in the subject, and the M1 macrophage polarization results in a macrophage-mediated inflammatory response.
A method for macrophage polarization in a subject in need thereof, comprising administering to the subject an effective amount of
- (a) a pyruvate kinase M2 (PKM2) antibody, wherein the macrophage polarization is between M1 and M2;
- or
- (b) pyruvate kinase M2 (PKM2) or a mutant thereof, wherein upon contact with PKM2 or the mutant thereof, macrophages polarize from the M2 to the M1 phenotype.
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.