Novel polypeptide
AssigneeShanghai Puyou Biomedical Co., Ltd.
InventorsYinghao Zhang, Guirui Yan, Yao Wang, Wenhan Li
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Abstract
The present disclosure provides a novel polypeptide. Also provided is an ophthalmic composition for treating or preventing dry eye (DE) or DE associated disorders. Also provided is a method for treating or preventing DE or DE associated disorders, stimulating tears, stabilizing tear film or any combination thereof in a subject in need thereof, comprising administering to the subject an effective amount of the novel peptides. Also provided is a contact lenses care product comprising the novel peptides and the preparation method thereof.
Claims24
A method for treating an eye of a subject, the method comprising
- administering to the eye of the subject an artificial polypeptide of Formula (I):
- wherein X is a moiety comprising an amino acid sequence having at least 80% sequence identity to SEQ ID NO:
- 1, and
- Y is a moiety comprising 10 to 50 amino acid residues, at least 50% of which are selected from the group consisting of:
- isoleucine, valine, leucine, phenylalanine, cysteine, methionine, and alanine;
- and
- wherein Y comprises a total number of cysteines of less than 5,
- thereby treating the eye of the subject.
Dependencies are inferred from the claim text.