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US 2026/0078098 A1Published application
Process of making derivatives of substituted morpholines
AssigneeSupernus Pharmaceuticals, Inc.
InventorsYanjun Sun, Bhaskara Rao Nallaganchu, Gary L. Olson
Life of this patent
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Abstract
Provided here are methods of making derivatives and prodrugs of substituted morpholines or pharmaceutically acceptable salts thereof. Further provided are methods of making derivatives and prodrugs of substituted morpholines having the following chemical structure:
Claims32
A compound of formula (IIc):
- wherein R1 is C1-C6 alkyl, aryl, heteroaryl, or heterocycloalkyl;
- each R2 is independently selected from F, Cl, Br, I, CN, NO2, C1-C6 alkyl, aryl, heteroaryl, or heterocycloalkyl;
- R3 is a C1-C6 alkyl;
- and nis 1.
1 more element
A compound of formula (IIc):
- wherein R1 is C1-C6 alkyl, aryl, heteroaryl, or heterocycloalkyl;
- each R2 is independently selected from F, Cl, Br, I, CN, NO2, C1-C6 alkyl, aryl, heteroaryl, or heterocycloalkyl;
- R3 is a C1-C6 alkyl;
- and n is 2.
1 more element
A compound of formula (IIc):
- wherein R1 is C1-C6 alkyl, aryl, heteroaryl, or heterocycloalkyl;
- each R2 is independently selected from F, Cl, Br, I, CN, NO2, C1-C6 alkyl, aryl, heteroaryl, or heterocycloalkyl;
- R3 is a C1-C6 alkyl;
- and n is 3.
1 more element
A compound of formula (IIc):
- wherein R1 is C1-C6 alkyl, aryl, heteroaryl, or heterocycloalkyl;
- each R2 is independently selected from F, Cl, Br, I, CN, NO2, C1-C6 alkyl, aryl, heteroaryl, or heterocycloalkyl;
- R3 is a C1-C6 alkyl;
- and n is 4.
1 more element
Dependencies are inferred from the claim text.