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US 2026/0078093 A1Published application
(4r)-3-(4-fluoro-2-hydroxyphenyl)-4-methyl-4,5-dihydro-1h-pyrazole-1-carboximidamide hydrochloride and dermal formulations thereof
AssigneeImmunahr AB
InventorLars PETTERSSON
Life of this patent
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Abstract
The present invention relates to the compound (4R)-3-(4-fluoro-2-hydroxyphenyl)-4-methyl-4,5-dihydro-1H-pyrazole-1-carboximidamide hydrochloride, to its enantioselective preparation, to a dermal formulation comprising the compound and one or more pharmaceutically acceptable excipients or carriers, and to the use of the compound as a medicament, particularly for use in the treatment of skin fibrosis.
Claims16
A compound (4R)-3-(4-fluoro-2-hydroxyphenyl)-4-methyl-4,5-dihydro-1H-pyrazole-1-carboximidamide hydrochloride.
13-16. (canceled)
A compound selected from the group consisting of:
- 3-(2-(Benzyloxy)-4-fluorophenyl)-4-methylene-4,5-dihydro-1H-pyrazole-1-carboximidamide;
- 3-(2-(Benzyloxy)-4-fluorophenyl)-4-methylene-4,5-dihydro-1H-pyrazole-1-carboximidamide trifluoroacetic acid salt;
- 3-(2-(Benzyloxy)-4-fluorophenyl)-4-methylene-4,5-dihydro-1H-pyrazole-1-carboximidamide methanesulfonic acid salt;
- (R)-3-(2-(Benzyloxy)-4-fluorophenyl)-4-methyl-4,5-dihydro-1H-pyrazole-1-carboximidamide;
- and
- (R)-3-(4-fluoro-2-hydroxyphenyl)-4-methyl-4,5-dihydro-1H-pyrazole-1-carboximidamide.
3 more elements
18-19. (canceled)
A compound
- (R)-3-(4-fluoro-2-hydroxyphenyl)-4-methyl-4,5-dihydro-1H-pyrazole-1-carboximidamide di-O,O′-p-toloyl-D-tartaric acid salt.
Dependencies are inferred from the claim text.