KARI Nanoparticle
AssigneeLa Jolla Institute for Immunology
InventorsEduardo Olmedillas, Erica Ollmann Saphire
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Abstract
This disclosure provides self-assembling Ketol-acid reductoisomerase (KARI) nanoparticles that are capable of displaying multiple copies of antigens, antibodies and/or proteins or peptides on its surface; as well as nucleic acids encoding recombinant KARI molecules, vectors expressing recombinant KARI molecules, immunogenic polypeptides comprising the self-assembling KARI nanoparticles, methods of producing the self-assembling KART nanoparticles, and methods for eliciting an immune response against an antigen in a subject comprising the self-assembling KARI nanoparticles.
Claims31
A self-assembling nanoparticle comprising an amino acid sequence of a recombinant Ketol-acid reductoisomerase (KARI;
- EC 1.1.1.86) and a tether sequence operably linking the KARI to at least one protein or peptide of interest wherein each protein comprises a capture sequence.
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An immunogenic conjugate comprising:
- (a) a self-assembling nanoparticle comprising an amino acid sequence of a recombinant Ketol-acid reductoisomerase (KARI;
- EC 1.1.1.86), and a tether sequence;
- (b) a protein of interest comprising a capture sequence;
- wherein the capture sequence and the tether sequence form a covalent bond that operably links the self-assembling nanoparticle to the protein of interest.
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Dependencies are inferred from the claim text.