Nucleic acids encoding human endogenous retrovirus k (herv-k) envelope proteins containing modified immunosuppressive domains (isd) and uses thereof
AssigneeInprother Aps
InventorsPeter HOLST, Christian THIRION, Lasse NEUKIRCH
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Abstract
A vaccine for use in the prophylaxis and/or treatment of a disease The present invention relates to an adenoviral vector capable of encoding a virus-like particle (VLP), said VLP displaying an inactive immune-suppressive domain (ISD). The vaccine of the invention shows an improved immune response from either of both of the response pathways initiated by CD4 T cells or CD8 T cells.
Claims21
-14. (canceled)
A nucleic acid molecule encoding an endogenous retrovirus (ERV) envelope protein or an immunogenic part thereof, wherein the immune-suppressive domain (ISD) of said protein contains at least one mutation that renders the ISD inactive.
Dependencies are inferred from the claim text.