# US 2026/0076933 A1 · Collagen production promoter, wrinkle improver, topical skin care composition, and beauty food or beverage

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- Number: US 2026/0076933 A1
- Document ID: US20260076933A1
- Status: Published application
- Kind: A1
- Application number: 19/398,828
- Filed: 2025-11-24
- Published: 2026-03-19
- Earliest claimed: 2019-07-31
- Assignees: Refine Holdings Co., Ltd.
- Applicants: Refine Holdings Co., Ltd.
- Inventors: Makoto TSUBOI; Kunimitsu KAYA; Fujio SHIRAISHI; Seiji SAKAMOTO; Izumi IWATA
- Web page: https://patentgrep.com/patent/US20260076933A1

## CPC

- A61K 31/20: having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A23L 33/12: Fatty acids or derivatives thereof
- A61K 8/361: {Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof}
- A61K 8/375: {the alcohol moiety containing more than one hydroxy group}
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 31/23: of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61P 17/00: Drugs for dermatological disorders
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61Q 19/08: Anti-ageing preparations
- A61K 2800/92: Oral administration
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Provided is a collagen production promoter comprising, as an active ingredient, a triglyceride represented by the following formula (I), wherein R1, R2 and R3 each denotes a saturated fatty acid residue, at least one of which is a pentadecanoic acid residue. The triglyceride comprising the pentadecanoic acid promotes the production of skin fibroblasts and collagen, and can be used as a topical skin care composition and a beauty food or beverage for improving the condition of skin.

## Claims

### Claim 1

A method for improving wrinkle of skin in a subject in need thereof, comprising administering to the subject a composition containing an effective amount of triglyceride represented by the following formula (I):
wherein R1, R2 and R3 each denotes a saturated fatty acid residue, at least one of which is a pentadecanoic acid residue.

### Claim 2 (depends on 1)

The method for improving wrinkle of skin in a subject according to claim 1, wherein the composition is a topical skin care composition.

### Claim 3 (depends on 1)

The method for improving wrinkle of skin in a subject according to claim 1, wherein the composition is a food or beverage composition.