External baroreflex activation for assessment and treatment
AssigneeCVRx, Inc.
InventorsDimitrios Georgakopoulos, Ivana Stojanovic, Nadim Yared
Life of this patent
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Abstract
Devices, systems and methods for non-invasive modulation of the baroreflex system of a patient. In embodiments, the present disclosure may be used to measure and monitor baroreflex function for diagnostic purposes in patients acutely or chronically to inform and guide medical treatment, assess disease severity, or assess morbidity/mortality risk. In embodiments, the present disclosure may be used to provide non-invasive baroreflex activation therapy acutely or chronically to treat a variety of disease conditions through rebalancing of the sympathetic and parasympathetic limbs of the autonomic nervous system and their connections to higher brain centers.
Claims20
A method for delivering personalized baroreflex modulation therapy to a patient, comprising:
- detecting a physiological parameter indicative of autonomic nervous system function using at least one biosensor integrated into a wearable baroreflex activation collar;
- determining whether the detected physiological parameter meets a predefined therapeutic trigger criterion;
- and
- delivering a tailored baroreflex activation regimen to the patient using the wearable collar device externally positioned at the carotid sinus region.
A method for delivering personalized baroreflex modulation therapy to a patient, comprising:
- positioning a wearable baroreflex activation collar on the patient's neck such that one or more pressure ports are aligned with a carotid sinus region;
- detecting, with at least one onboard or auxiliary sensor, a physiological parameter indicative of autonomic nervous system function;
- comparing the detected parameter to a patient-specific trigger;
- applying pneumatic pressure through the aligned pressure ports to deliver a baroreflex activation regimen when the trigger is met;
- and
- dynamically adjusting at least one of amplitude, duration, frequency, polarity, waveform class, or port selection in real time based on the detected physiological parameter, while providing a manual or automatic override to revert to open-loop operation under predefined safety conditions.
A method for delivering personalized baroreflex modulation therapy to a patient, comprising:
- executing a patient-specific calibration by delivering graded pneumatic stimuli through collar pressure ports at multiple predefined intensities and recording corresponding physiological responses;
- generating a dose-response profile and at least one baroreflex trigger threshold from the calibration;
- and
- thereafter delivering therapy sessions that automatically initiate and adjust pneumatic actuation through selected pressure ports when sensed parameters meet the trigger threshold, according to the dose-response profile.
Dependencies are inferred from the claim text.