# US 2026/0076360 A1 · Organ Perfusion Machine

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- Number: US 2026/0076360 A1
- Document ID: US20260076360A1
- Status: Published application
- Kind: A1
- Application number: 19/136,552
- Filed: 2023-11-14
- Published: 2026-03-19
- Earliest claimed: 2022-12-13
- Assignees: Shimadzu Corporation; Kyoto University
- Applicants: Shimadzu Corporation; Kyoto University
- Inventors: Takeru KUNIMITSU; Minoru KASHIHARA; Koichiro HATA; Tetsuya TAJIMA
- Web page: https://patentgrep.com/patent/US20260076360A1

## CPC

- A01N 1/142: Apparatus
- A01N 1/143: for organ perfusion
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS

## Abstract

An organ perfusion apparatus includes a chamber that is open to an atmosphere and houses an organ, an inflow channel that receives a perfusion fluid to be sent to the organ, and an outflow channel connectable, at one end, to an inlet blood vessel of the organ for sending the perfusion fluid received by the inflow channel toward the inlet blood vessel. The chamber includes a connecting port configured to be openable and closable and configured to be connectable to the inflow channel. In the organ perfusion apparatus, a connector of the inflow channel which receives the perfusion fluid is connected to the connecting port to configure an open system circuit, and the connecting port is closed and a connector of the inflow channel which receives the perfusion fluid is connected to an outflow blood vessel of the organ to configure a closed system circuit.

## Claims

### Claim 1

An organ perfusion machine for perfusing an organ with a perfusate, the organ perfusion machine comprising:
a chamber that is open to an atmosphere and houses the organ;
an inflow channel connected to an inlet blood vessel of the organ; and
one or more outflow channels fluidly connected to the inflow channel and disposed on an outlet blood vessel side of the organ, wherein
the chamber includes a connecting port that is openable and closable, the connecting port being connectable to the one or more outflow channels,
the one or more outflow channels are configured to be selectively connectable to one of the connecting port and the outflow blood vessel,
the one or more outflow channels are connected to the connecting port to configure an open system circuit, and
the one or more outflow channels are connected to the outflow blood vessel to configure a closed system circuit.

### Claim 2 (depends on 1)

The organ perfusion machine according to claim 1, wherein the connecting port is provided on a bottom of the chamber.

### Claim 3 (depends on 2)

The organ perfusion machine according to claim 2, wherein
the chamber includes a protrusion provided on a bottom surface thereof and protruding outward opposite to a side of the chamber on which the organ is received, and
the connecting port is provided on the protrusion.

### Claim 4 (depends on 1)

The organ perfusion machine according to claim 1, further comprising a reservoir that stores the perfusate, wherein
the one or more outflow channels include
a first channel connected to the reservoir and selectively connected to the connecting port to configure the open system circuit, and
a second channel connected to the reservoir and selectively connected to the outflow blood vessel to configure the closed system circuit, and
the first channel has a channel sectional area larger than a channel sectional area of the second channel.

### Claim 5 (depends on 4)

The organ perfusion machine according to claim 4, further comprising:
a refill channel that is connected to the reservoir and receives the perfusate to refill the reservoir;
a valve that opens or closes the refill channel;
a fluid level sensor that measures a fluid level height of the perfusate in the reservoir; and
a controller,
wherein the controller performs refill control of opening the valve to refill the reservoir with the perfusate when the fluid level height is less than a first threshold.

### Claim 6 (depends on 5)

The organ perfusion machine according to claim 5, wherein the controller performs the refill control when the closed system circuit is used.