Printable molecule-selective core-shell nanoparticles for wearable and implantable sensing

Abstract

Printable, molecule-selective core-shell nanoparticles that couple a redox-active core with a molecularly imprinted polymer (MIP) shell. The core may comprise nickel hexacyanoferrate nanocubes with improved redox stability in physiological media. A thin MIP shell may be formed by templated copolymerization (e.g., methacrylic acid with ethylene glycol dimethacrylate) around the nanocubes, followed by template extraction to generate target-complementary binding cavities. Monomer selection may be guided computationally to maximize binding energy and selectively for a chosen analyte. Target binding within the MIP shell may modulate interfacial electron transfer at the core, enabling more robust and reversible electrochemical transduction. The nanoparticles may be formulated into stable, inkjet-printable dispersions via optimized solvent systems and exhibit cytocompatibility, anti-biofouling behavior, thermal resilience, and long room-temperature shelf stability.

Dependencies are inferred from the claim text.