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US 2026/0072017 A1Published application
Methods of detecting off-target binding of proteins
AssigneeAmgen Inc.
InventorsMelissa YANG, Marissa MOCK, René Simon HUBERT, Wenchao SUN
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Abstract
The present invention relates to methods of detecting off-target binding of proteins such as antibodies. Said methods are useful in identifying proteins that are likely to have more rapid clearance in vivo compared to proteins that do not have (or they have less) off-target binding.
Claims19
A method of detecting off-target binding of a protein, the method comprising detecting binding of the protein to polyethyleneimine (PEI).
Dependencies are inferred from the claim text.