US 2026/0071233 A1 · RECOMBINANT VIRUS EXPRESSING INTERLEUKIN-12

Recombinant virus expressing interleukin-12

AssigneesTransgene S.A., AstraZeneca AB

InventorsMichael David OBERST, Maria Anna Sofia BROGGI, Nicholas DURHAM, Elizabeth J. KELLY, Jason Paul LALIBERTE, Noèlia Purroy ZURIGUEL, Djuro KARANOVIC, Scott Alan HAMMOND, Nathalie Josette SILVESTRE, Johann Daniel Valéry FOLOPPE

Life of this patent

Estimating the term…

Abstract

The present disclosure relates to a recombinant poxvirus comprising in its genome a heterologous nucleic acid sequence encoding interleukin-12 (IL-12). Methods for producing the recombinant poxvirus, compositions (e.g., pharmaceutical compositions) comprising the recombinant poxvirus, methods of treating cancer using the recombinant poxvirus, and kits comprising the recombinant poxvirus are provided.

Claims78

Dependent claims

A recombinant poxvirus comprising in its genome a heterologous nucleic acid sequence encoding interleukin-12 (IL-12),

wherein the heterologous nucleic acid sequence encoding IL-12 is operably linked to a late or intermediate promoter.

Dependencies are inferred from the claim text.