Monobody and NK Cells

Abstract

The present invention provides a novel substance that stably binds to a surface protein expressed on NK cells. The present invention provides a monobody that binds to a surface protein of an NK cell, wherein the monobody has an amino acid sequence of any one of (1) to (3): (1) an amino acid sequence represented by any one of SEQ ID NOs: A1 to A12; (2) an amino acid sequence given by deletion, substitution, and/or addition of one or more amino acids in an amino acid sequence represented by any one of SEQ ID NOs: A1 to A12 excluding arbitrary amino acids; and (3) an amino acid sequence having an identity of 80% or more with an amino acid sequence represented by any one of SEQ ID NOs: A1 to A12 excluding arbitrary amino acid sequences, wherein X1, X2, X3, X4, X5, and X6 in SEQ ID NOs: A1 to A12 each independently represent an arbitrary amino acid, and n1, n2, n3, n4, n5, and n6 each independently represent an arbitrary natural number. X1n1 X2n2 X3n3 (SEQ ID NO: A1) PIWGRYGT TVRGQTYYWWML X1n1 X2n2 X3n3 (SEQ ID NO: A2) WTWLGYEYYW WDSKPGAIGI X1n1 X2n2 X3n3 (SEQ ID NO: A3) TYWDWGFR WSWARRTHISWF X4n4 X5n5 X6n6 (SEQ ID NO: A4) PGYYMWQRGVIN GQERAYGHPEHF X4n4 X5n5 X6n6 (SEQ ID NO: A5) RYKYHRRIN GTQWYVFNEAGDVAGY X1n1 X2n2 X3n3 (SEQ ID NO: A6) GPIVSYSWWYHW VGYVNEKYDAWQSYVQ X1n1 X2n2 X3n3 (SEQ ID NO: A7) QAYWFEYTWW LEVVYDDQWTSG X4n4 X5n5 X6n6 (SEQ ID NO: A8) TSPWYNGY DQYKSWNLEEFH X4n4 X5n5 X6n6 (SEQ ID NO: A9) TPPWIHKGW VTPYGRKWVGMNGW X1n1 X2n2 X3n3 (SEQ ID NO: A10) LWHYYGDQYW WMYVPEYYFNPW X1n1 X2n2 X3n3 (SEQ ID NO: A11) TDRNYDITYGMQ YWWDGYSYSEEAWYY X4n4 X5n5 X6n6 (SEQ ID NO: A12) WSWESYWHGTY TFMKDIPSYY

Dependencies are inferred from the claim text.