Single domain antibodies targeting hpv e6/e7 oncogenic peptide/mhc complexes
AssigneeThe U.S.A., as represented by the Secretary, Department of Health and Human Services
InventorsMitchell Ho, Zhijian Duan, Christian S. Hinrichs
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Abstract
Single-domain antibodies that specifically bind human papillomavirus (HPV) E6 or E7 oncogenic peptides in complex with human major histocompatibility complex (MHC) proteins are described. The E6-MHC-specific and E7-MHC-specific single-domain antibodies were isolated from dromedary camel (VHH) antibody libraries by panning the library with an E6- or E7-derived peptide in complex with HLA-A*02:01. Use of the single-domain antibodies for the detection and treatment of HPV-associated cancers and pre-cancerous lesions is also described.
Claims42
A polypeptide that specifically binds a human papillomavirus (HPV) E6 or E7 peptide in complex with an MHC class I molecule, wherein the polypeptide comprises the complementarity determining region 1 (CDR1), CDR2 and CDR3 sequences of SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4 or SEQ ID NO:
- 5.
3-6. (canceled)
(canceled)
15-16. (canceled)
20-22. (canceled)
(canceled)
(canceled)
32-33. (canceled)
(canceled)
45-46. (canceled)
(canceled)
Dependencies are inferred from the claim text.