Substituted biphenyl or phenylheteroaryl-mannosides as antagonists of fimh
AssigneesGlaxoSmithKline Intellectual Property Development Limited, Fimbrion Therapeutics, Inc.
InventorsMichael Joseph BISHOP, James Walter JANETKA, Laurel Kathryn MCGRANE, Katherine Louisa WIDDOWSON
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Abstract
Disclosed herein are new C-mannoside compounds and compositions and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in human subjects are also provided for the treatment diseases such as urinary tract infection.
Claims12
1-21. (canceled)
A method for the treatment or prevention of a disease selected from the group consisting of a bacterial infection, Crohn's disease (CD), and Inflammatory Bowel Disease (IBD) comprising the administration, to a human patient in need thereof, of a therapeutically effective amount of a compound I or a pharmaceutically acceptable salt thereof
- in which
- Z is
- wherein
- X is CH3, Cl, or CF3;
- Y is H or F;
- and
- each of R1, R2, R3, R12, R13, R14, R15, R16, R17, R22, R23, and R24 are independently selected from the group consisting of hydrogen, CN, F, C3-6cycloalkyl, C1-6alkyl, —N(C1-4alkyl)2, —OC1-6alkyl, CF3, and
Dependencies are inferred from the claim text.