Method for manufacturing electrophilic substituted aromatic compound

Abstract

Disclosed is a method for manufacturing an electrophilic substituted aromatic compound, including continuously carrying out, by a flow-type reaction, a reaction in which a halogenated aromatic compound is reacted with an organometallic compound to produce a metallated aromatic compound, and the metallated aromatic compound is reacted with an electrophilic compound to produce an electrophilic substituted aromatic compound, in which the method includes allowing a liquid containing the halogenated aromatic compound in an organic solvent, a liquid containing the organometallic compound in an organic solvent, and a liquid containing the electrophilic compound in an organic solvent to flow in a flow channel, with each liquid having a moisture content of 200 ppm or less.

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