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US 2026/0070907 A1Published application
Functionalized lactams as modulators of the 5-hydroxytryptamine receptor 7 and their method of use
AssigneesTemple University of the Commonwealth System of Higher Education, Praeventix, LLC
InventorsDaniel J. Canney, Benjamin E. Blass, Kevin M. Blattner, Douglas A. Pippin
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Abstract
Pharmaceutical compositions of the invention comprise functionalized lactam derivatives having a disease-modifying action in the treatment of diseases associated with dysregulation of 5-hydroxytryptamine receptor 7 activity.
Claims24
A compound of Formula (II):
- wherein:
- R1 and R2 are each ethyl,
- n is 2, and
- R3 is 4-F-phenyl,
- or a pharmaceutically acceptable salt or enantiomer thereof.
2 more elements
A compound of Formula (X):
- wherein:
- n is 2, and
- R3 is 4-F-phenyl,
- or a pharmaceutically acceptable salt or enantiomer thereof.
1 more element
A compound of Formula (XI):
- wherein:
- n is 2, and
- R3 is 4-F-phenyl,
- or a pharmaceutically acceptable salt or enantiomer thereof.
1 more element
A compound of Formula (VIII) or (IX):
- wherein:
- n is 2, and
- R3 is 4-F-phenyl, and
- or a pharmaceutically acceptable salt or enantiomer thereof.
1 more element
Dependencies are inferred from the claim text.