TARGETING moDC TO ENHANCE VACCINE EFFICACY ON MUCOSAL SURFACE
OwnerLei JIN, Samira MANSOURIinventors
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Abstract
Described herein are novel vaccine compositions and methods for use thereof in inducing an immune response in a subject especially aged subjects. Specifically exemplified are vaccine compositions that include an antigen; a cyclic dinucleotide; soluble tumor necrosis factor (TNF); or a CD64 antibody or antibody fragment. Optionally, the vaccine composition comprises a TNF conjugated with a moDC targeting moiety in addition to or in place of TNF or CD64 antibody or antibody fragment, or both TNF and CD64 antibody or antibody fragment.
Claims16
An adjuvant composition comprising a cyclic dinucleotide, soluble tumor necrosis factor (sTNF);
- transmembrane TNF (tmTNF) and a CD64 antibody or antibody fragment;
- or optionally, a TNF conjugated with a moDC targeting moiety in addition to or in place of TNF or CD64 antibody or antibody fragment, or both TNF and CD64 antibody or antibody fragment.
An adjuvant composition comprising TNF conjugated with an moDC targeting moiety.
A vaccine composition comprising a therapeutically effective amount of
- an antigen;
- a cyclic dinucleotide;
- and
- a TNF conjugated with a moDC targeting moiety.
Dependencies are inferred from the claim text.