Compositions and methods for inducing immune responses
AssigneeArcturus Therapeutics, Inc.
InventorsSean Michael SULLIVAN, Daiki MATSUDA, Kiyoshi TACHIKAWA, Padmanabh CHIVUKULA, Priya Prakash KARMALI, Jared Henry DAVIS, Yanjie BAO
Life of this patent
Estimating the term…
Abstract
Provided herein are nucleic acid molecules encoding viral replication proteins and antigenic proteins or fragments thereof. Also provided herein are compositions that include nucleic acid molecules encoding viral replication and antigenic proteins, and lipids. Nucleic acid molecules provided herein are useful for inducing immune responses.
Claims40
A lipid nanoparticle comprising:
- A) a nucleic acid molecule comprising:
- (i) a first polynucleotide encoding a polyprotein comprising viral replication proteins, wherein the polyprotein comprises a sequence having at least 80% identity to the sequence of SEQ ID NO:79;
- and
- (ii) a second polynucleotide comprising a first transgene encoding a first antigenic protein or a fragment thereof;
- and
- B) an ionizable cationic lipid.
-7. (canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
-74. (canceled)
-78. (canceled)
-86. (canceled)
Dependencies are inferred from the claim text.