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AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsAvnesh S. Thakor, Shashank Chetty, Shobha Regmi, Abantika Ganguly
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Methods for treating diseases associated with inflammation driven cellular-energy deficiency or mitochondrial dysfunction are provided. The methods utilize extracellular vesicles derived from mesenchymal stromal cells (MSCs) that have been stimulated with sound waves. The use of pFUS stimulation at low acoustic doses enhances the production and bioenergetic profile of extracellular vesicles from MSCs. The extracellular vesicles derived from MSCs that have been stimulated with sound waves can be used to reduce inflammation, restore the bioenergetic health of injured cells, and promote regeneration of injured tissue through the release of the extracellular vesicle cargo, which contains mitochondria-related products.
A method of treating a subject for a disease or condition associated with cellular-energy deficiency or mitochondrial dysfunction, the method comprising:
A composition comprising extracellular vesicles derived from a mesenchymal stromal cell that has been stimulated with sound waves for use in a method of treating a disease or condition associated with cellular-energy deficiency or mitochondrial dysfunction.
A method of improving metabolic health of a damaged, exhausted, or diseased cell, the method comprising:
Dependencies are inferred from the claim text.