Compositions for Drug Delivery and Methods of Use Thereof
AssigneeStellular Bio, Inc.
InventorsJonathan N. Thon, Brad Dykstra, Brenden William Smith, Christian Gerald Peters, Thomas Carl Schulz
Life of this patent
Estimating the term…
Abstract
Methods for producing megakaryoctyres and platelets derived from inducible pluripotent stem cells are provided. Such megakaryocytes or platelets can be genetically modified to comprise a nucleic acid molecule encoding a therapeutic agent. The present disclosure further provides methods and compositions for loading a platelet or a megakaryocyte with a therapeutic agent and for genetically modifying a platelet or a megakaryocyte to express an agent.
Claims16
A composition comprising a population of platelets derived from induced pluripotent stem cells (iPSCs), wherein the platelets exhibit increased thrombin generation relative to a population of donor derived platelets having a similar cell density.
The composition of claim 5, wherein the lag time of achieving a maximum thrombin concentration in the population of platelets derived from induced pluripotent stem cells is between about 7 and 13 minutes, and wherein the population comprises between about 0.5×106 platelets/mL and 3×106 platelets/mL, respectively.
Dependencies are inferred from the claim text.