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US 2026/0069172 A1Published application
Diffusion layer for an enzymatic in-vivo sensor
OwnerGregor Ocvirk, Angelika Fuerst +2inventors
InventorsGregor Ocvirk, Angelika Fuerst, Alexander Steck, Juergen Woehrle
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Abstract
The present disclosure relates to an electrode system for measuring the concentration of an analyte under in-vivo conditions, comprising an electrode with immobilized enzyme molecules and a diffusion barrier that controls diffusion of the analyte from body fluid surrounding the electrode system to the enzyme molecules.
Claims21
An electrode system for measuring the concentration of an analyte under in-vivo conditions, comprising:
- an electrode having immobilized enzyme molecules and a diffusion barrier configured to control diffusion of the analyte from the exterior of the electrode system to the enzyme molecules;
- the diffusion barrier comprising a block copolymer having from 75 to 95 mol % of a HEMA block and from 5 to 25 mol % of a hydrophobic block of n-BuA or EA, based on the total amount (mol) of the block copolymer in a dry state;
- wherein the glass transition temperature of the hydrophobic block is in the range of about −80° C. and about 0° C.;
- and
- wherein subjecting a sensor having the electrode system to a 1 mm bending radius avoids indicia of Newton's Rings and/or a sensor having the electrode system has a sensitivity in the range of 1 to 1.5 nA/mM analyte.
2 more elements
Dependencies are inferred from the claim text.