US 2026/0066053 A1Published application

System and method for improved genetic modifications to support beneficial adaptation to unanticipated conditions and unintended consequences by utilizing randomization

OwnerJohn McDevittinventor

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Abstract

A system and method that provides a rule-based process utilizing a managed randomization procedure for the purpose of improved genetic modification. The system includes a database that stores specific genetic sequences. Additionally, included is a genetic sequence rules engine that generates a sequence of approved genetic content based on genetic characteristics rules and a predictive rules engine that produces genetic sequence content selection characteristics based on biologic goal(s). A randomization engine is applied to the planned genetic sequence to build a set of alternate genetic sequences. Furthermore, by applying the generated genetic characteristics rules to the list of approved genetic elements to select genetic edits, such that the targeted genetic characteristics are optimized, and negative characteristics are minimized in accordance with the goal(s) of the process. This process may occur in a computer test environment, a controlled laboratory environment, and/or the natural environment.

Claims10

Dependent claims

A system for generating and selecting a randomized genetic structure that is robust to unanticipated conditions, the system comprising:

(a) at least one electronic database storing:
(i) existing genetic content to be edited,
(ii) new genetic content to be added, and
(iii) genetic content to be removed;
and
(b) at least one processor with software instructions stored thereon that, when executed, cause the at least one processor to:
(1) receive ecosystem rules and goals defining inclusions, exclusions, prioritizations, or likelihoods for genetic edits, and generate therefrom base genetic structure rules that satisfy the ecosystem rules and goals;
(2) receive genetic structure results and other historical results associated with prior genetic editing to generate predictive rules and combine the predictive rules with the base genetic structure rules to form a genetic structure rule set representing a best-guess genetic structure;
(3) apply a randomization of genetic structure rules engine using randomization rules to the genetic structure rule set to produce a plurality of randomized genetic structures, each randomized genetic structure being constrained by the ecosystem rules and goals and by the base genetic structure rules, the randomization being performed to increase a likelihood of meeting the ecosystem goals in view of complex inter-related systems, unanticipated conditions, or unintended results;
(4) for the plurality of randomized genetic structures, determine a weighing for at least a selected subset of the randomized genetic structures based on at least one of:
(i) alignment with the ecosystem rules and goals, (ii) alignment with historical results, and (iii) a prioritization contained in the randomization rules;
and compute, from the determined weighing, a probability that at least one finalized genetic structure will satisfy the ecosystem goals;
(5) select, according to the determined weighing and probability, at least one of the randomized genetic structures and generate the selected genetic structure by editing the existing genetic content to add the new genetic content, remove the genetic content to be removed, or move genetic content, such that the created edited genetic content is most likely in compliance with the ecosystem rules and goals;
(6) enable the edited genetic content to exhibit results of the editing to form a finalized genetic structure and evaluate the results relative to the ecosystem rules and goals;
and
(7) periodically or continuously update at least one of the predictive rules, the randomization rules, and the genetic structure rule set based on the evaluated results, such that subsequent randomizations use updated data.

13 more elements

A method for generating and selecting a randomized genetic structure that is robust to unanticipated conditions, the method comprising:

(a) storing, in at least one electronic database,
(i) existing genetic content to be edited,
(ii) new genetic content to be added, and
(iii) genetic content to be removed;
(b) receiving ecosystem rules and goals that define inclusions, exclusions, prioritizations, or likelihoods for genetic edits based on at least one of source of genetic content, impact of genetic content, ethics, legal considerations, business considerations, impacts on future generations, or impact on an ecosystem, and generating, from the ecosystem rules and goals, base genetic structure rules that satisfy the ecosystem rules and goals;
(c) receiving genetic structure results and other historical results associated with prior genetic editing and generating predictive rules therefrom, and combining the predictive rules with the base genetic structure rules to form a genetic structure rule set that represents a best-guess genetic structure most likely to achieve the ecosystem goals;
(d) applying, to the genetic structure rule set, a randomization of genetic structure rules engine using randomization rules to produce a plurality of randomized genetic structures, each of the plurality of randomized genetic structures being constrained by the ecosystem rules and goals and by the base genetic structure rules, the applying being performed to increase a likelihood of achieving the ecosystem goals in view of complex inter-related systems, unanticipated conditions, or unintended results;
(e) for the plurality of randomized genetic structures, determining a weighing for at least a selected subset of the randomized genetic structures based on at least one of:
(i) degree of alignment with the ecosystem rules and goals,
(ii) degree of alignment with the genetic structure results and the other historical results, and
(iii) a prioritization specified in randomization rules;
and computing, from the determined weighing, a probability that at least one finalized genetic structure will satisfy the ecosystem goals;
(f) selecting, according to the determined weighing and the computed probability, at least one of the randomized genetic structures and generating the selected genetic structure by editing the existing genetic content to add the new genetic content, remove the genetic content to be removed, or move genetic content, such that the created edited genetic content is most likely in compliance with the ecosystem rules and goals;
(g) enabling the edited genetic content to exhibit results of the editing to produce a finalized genetic structure and evaluating the results of the editing relative to the ecosystem rules and goals;
and
(h) periodically or continuously updating at least one of the predictive rules, the randomization rules, and the genetic structure rule set based on the evaluated results, such that a subsequent application of the randomization of genetic structure rules engine uses the updated rules and results.

13 more elements

Dependencies are inferred from the claim text.

Facts

Application: 19/382,248Filed 6 Nov 2025
Priority: 16 Dec 2019
Published: 5 Mar 2026
Term ends: Not estimatedThe source records don’t support an estimate.

Classification8 codes

G16B 50/20
ICT programming tools or database systems specially adapted for bioinformatics: heterogeneous data integration
G06N 5/02
Computing arrangements using knowledge-based models: knowledge representation; Symbolic representation
G06N 5/04
Computing arrangements using knowledge-based models: inference or reasoning models
G06N 5/046
Inference or reasoning models: forward inferencing; Production systems

Family

Application62/948,782Us provisional application · filed 16 Dec 2019
Application17/121,675Continuation · filed 14 Dec 2020
Application18/734,414Continuation · filed 5 Jun 2024
Application19/382,248Continuation
US 12,094,576 B2Related patent
US 2021/0183475 A1Published application
US 2024/0347138 A1Published application
US 2026/0066053 A1This patent

From the US filing history. Foreign family members aren’t listed.