# US 2026/0065698 A1 · Methods and systems for tracking biological material

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- Number: US 2026/0065698 A1
- Document ID: US20260065698A1
- Status: Published application
- Kind: A1
- Application number: 19/380,046
- Filed: 2025-11-05
- Published: 2026-03-05
- Earliest claimed: 2023-04-03
- Assignees: CooperSurgical, Inc.
- Applicants: CooperSurgical, Inc.
- Inventors: Charles Paradise; Michael Gerbush; Milan Ivosevic; Brian Costello; Paul DiCesare; Danial Ferreira; Ronald Green
- Web page: https://patentgrep.com/patent/US20260065698A1

## CPC

- G06V 20/69: Microscopic objects, e.g. biological cells or cellular parts
- G06V 20/698: {Matching; Classification}
- G06T 7/40: Analysis of texture (depth or shape recovery from texture G06T7/529)
- G06V 10/25: Determination of region of interest [ROI] or a volume of interest [VOI]
- G06V 10/764: using classification, e.g. of video objects
- G06V 10/774: Generating sets of training patterns; Bootstrap methods, e.g. bagging or boosting
- G16B 20/10: Ploidy or copy number detection
- G16H 10/40: for data related to laboratory analysis, e.g. patient specimen analysis
- G06T 2207/10056: Microscopic image
- G06T 2207/20081: Training; Learning
- G06T 2207/30024: Cell structures in vitro; Tissue sections in vitro
- G06V 2201/03: Recognition of patterns in medical or anatomical images
- G06V: IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
- G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G16B: BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA

## Abstract

The present disclosure relates to a method performed by one or more computers for tracking a biological material of a subject during an in-vitro fertilization process. The method includes receiving, from a camera, an image of a dish having a visual characteristic and a drop disposed on the dish, the dish holding the biological material at a drop location. The method then includes processing the image of the dish, using a drop identification model, to identify the drop according to the visual characteristic. Further, the method includes assigning an identifier to the drop associated with the drop location, and recording the identifier of the drop associated with the drop location.

## Claims

### Claim 1

A method performed by one or more computers for tracking a biological material of a subject during an assisted reproductive process, the method comprising:
receiving, from a camera, an image of a pipette and a drop disposed on a dish, the biological material being in the drop;
processing the image of the pipette and the drop; and
determining that the pipette has entered the drop upon identifying a meniscus created by the pipette and the drop.

### Claim 2 (depends on 1)

The method of claim 1, further comprising determining whether the biological material has entered the pipette.

### Claim 3 (depends on 2)

The method of claim 2, wherein determining whether the biological material has entered the pipette comprises processing a second image of the pipette and the drop.

### Claim 4 (depends on 3)

The method of claim 3, comprising determining that the biological material has entered the pipette when the biological material is identified inside the pipette.

### Claim 5 (depends on 3)

The method of claim 3, comprising receiving the second image from the camera.

### Claim 6 (depends on 3)

The method of claim 3, comprising receiving the second image from a second camera.

### Claim 7 (depends on 1)

The method of claim 1, wherein the meniscus is a first meniscus, and the method comprises identifying a second meniscus created by the pipette and a layer of liquid overlying the drop, wherein the first meniscus is closer to a distal end of the pipette than the second meniscus is to the distal end of the pipette.

### Claim 8 (depends on 7)

The method of claim 7, wherein the layer of liquid overlying the drop is a layer of oil.

### Claim 9 (depends on 1)

The method of claim 1, comprising receiving, from the camera, a second image of the pipette and a layer of liquid overlying the drop, and processing the second image of the pipette and the layer of liquid overlying the drop to determine whether the pipette has entered the layer of liquid.

### Claim 10 (depends on 1)

The method of claim 1, comprising receiving, from the camera, a second image of the pipette and the drop, and processing the second image of the pipette and the drop to determine whether the pipette has exited the drop.

### Claim 11 (depends on 10)

The method of claim 10, comprising determining that the pipette has exited the drop upon identifying an absence of the meniscus created by the pipette and the drop.

### Claim 12 (depends on 1)

The method of claim 1, wherein the drop disposed on the dish is a first drop located at a first drop location, and the method comprises identifying a first status or condition of the pipette at the first drop location; and
recording in a memory the first status or condition of the pipette.

### Claim 13 (depends on 12)

The method of claim 12, wherein identifying the first status or condition comprises determining that the pipette has entered the first drop.

### Claim 14 (depends on 12)

The method of claim 12, comprising identifying a second status or condition of the pipette at a second location.

### Claim 15 (depends on 14)

The method of claim 14, comprising analyzing the second status or condition of the pipette.

### Claim 16 (depends on 15)

The method of claim 15, comprising determining, before the biological material is delivered to the second location, that the second location correlates with a standard operating protocol stored in a database of the memory.

### Claim 17 (depends on 16)

The method of claim 16, comprising signaling an error message after determining that the second location does not correlate with the standard operating protocol.

### Claim 18 (depends on 14)

The method of claim 14, comprising recording a delivery status of the biological material from the pipette to the second location.

### Claim 19

One or more non-transitory computer storage media storing:
instructions that when executed by one or more computers cause the one or more computers to perform operations for tracking a biological material in an assisted reproductive process, the operations comprising:
receiving, from a camera, an image of a pipette and a drop disposed on a dish, the biological material being in the drop;
processing the image of the pipette and the drop; and
determining that the pipette has entered the drop upon identifying a meniscus created by the pipette and the drop.

### Claim 20

A system for tracking a biological material in an assisted reproductive process, the system comprising:
a microscope;
a camera;
one or more computers; and
one or more storage devices communicatively coupled to the one or more computers, wherein the one or more storage devices store:
instructions that, when executed by the one or more computers, cause the one or more computers to perform operations comprising:
receiving, from the camera, an image of a pipette and a drop disposed on a dish, the biological material being in the drop;
processing the image of the pipette and the drop; and
determining that the pipette has entered the drop upon identifying a meniscus created by the pipette and the drop.