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US 2026/0062679 A1Published application
Heparinized microsphere, method of preparing thereof and method of isolating exosomes
AssigneeNational Taiwan University of Science and Technology
InventorsHsieh-Chih TSAI, Shuian-Yin LIN, Kuan-Ju CHEN
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Abstract
A heparinized microsphere is provided, including a polymer, heparin and a cross-linking agent. The polymer has at least one functional group includes a hydroxyl group, a carboxyl group, an amine group, or a combination thereof. The polymer and the heparin are cross-linked by a cross-linking agent. A method of preparing heparinized microsphere and a method of isolating exosomes are also provided to achieve purification of exosomes with high purity.
Claims20
A heparinized microsphere, comprising:
- a polymer having at least one functional group, the at least one functional group comprising a hydroxyl group, a carboxyl group, an amino group, or a combination thereof;
- heparin;
- and
- a cross-linking agent, the polymer and the heparin cross-linked by the cross-linking agent.
1 more element
A method of preparing a heparinized microsphere, comprising:
- providing a polymer;
- and
- processing a mixing process with the polymer, heparin and a cross-linking agent, wherein when the polymer and the heparin are in contact with the cross-linking agent, cross-linking is performed to obtain the heparinized microsphere.
Dependencies are inferred from the claim text.