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US 2026/0062447 A1Published application
Compounds
AssigneeUniversity of Southampton
InventorsAli TAVASSOLI, Reece GARDNER
Life of this patent
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Abstract
The invention provides cyclic peptides that are able to disrupt the typical response to hypoxia and which have particular utility in the treatment of cancers and von Hippel-Lindau disease.
Claims44
A cyclic peptide, wherein the cyclic peptide has the following sequence:
- [Formula 1]
- [SEQ ID NO:
- 1]
- C X1 X2 X3 X4 X5
- wherein:
- i) C is selected from the group comprising or consisting of cys, h-cys and d-cys, optionally is cys;
- ii) X1 is selected from the group comprising or consisting of leu, lys and glu, optionally is lys or leu, optionally is lys;
- iii) X2 is:
- wherein:
- R1 is H or methyl;
- R2 is C1-C6 linear or branched alkyl, optionally substituted with —OC1-3 alkyl
- iv) X3 is:
- wherein:
- L1 is C1-C3 alkylene;
- R3 is selected from the group consisting of a C3-C6 cycloalkyl, a 5-6 membered ring and 8-10 membered bicyclic ring, wherein the rings are optionally substituted with phenyl, halogen, —OH, —O(C1-C3 alkyl), C1-C4 alkyl or C1-C4 haloalkyl;
- v) X4 is:
- wherein:
- R4 is H or methyl;
- R5 is C1-C6 linear or branched alkyl, optionally substituted with —OC1-3 alkyl;
- vi) X5 is:
- wherein:
- L2 is C1-C3 alkylene or a direct bond;
- R6 is selected from the group consisting of a C3-C6 cycloalkyl, 5-6 membered ring and 8-10 membered bicyclic ring, wherein the rings are optionally substituted with phenyl, halogen, —NO2, —OH, —O(C1-C3 alkyl), C1-C4 alkyl or C1-C4 haloalkyl;
- wherein:
21 more elements
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Dependencies are inferred from the claim text.