Novel dpp1 inhibitors and uses thereof
AssigneeInsmed Incorporated
InventorsAdam J. PLAUNT, David C. CIPOLLA, Adrien CERDAN, Paola CIAPETTI, Bastien GOEGAN, David J. AUGERI
Life of this patent
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Abstract
Provided herein are novel DPP1 inhibitor compounds having the general structure of Formula (I), (II) or (III), or a pharmaceutically acceptable salt thereof. Also provided are certain methods of treatment, e.g., a method for treating an obstructive disease of the airway or a method of treating an inflammatory condition with a composition comprising an effective amount of one of the compounds provided herein.
Claims34
A compound of Formula (I):
- or a pharmaceutically acceptable salt or deuterated form thereof, wherein,
- R1 is
- R2 is
- X1, X2 and X3 are independently O, S, NR3 or CR3R4;
- each R3, R4 and R5 is independently H, F, Cl, Br, I or C1-C6 alkyl;
- each R6 is independently H or C1-C6 alkyl;
- each Y is independently O, S, CHR6 or NR6;
- m and m′ are each independently an integer from 0-3, and the total sum of m and m′ is ≤3;
- each n, n′ and n″ is independently an integer from 0-3, and the total sum of n, n′ and n″ is ≤4;
- and
- L is
- provided that,
- (i) when R1 is
- and X1 is —CH2—, then L and R2 taken together, is not
- (ii) when R1 is
- then L and R2 taken together, is not
- (iii) when R1 is
- and L is
- then R2 is not
- (iv) when R1 is
- and L is
- then R2 is not
- (v) when R1 is
- and L is
- then R2 is not
- (vi) when R1 is
- and L is
- then R2 is not
- and
- (vii) when R1 is
- and L is
- then R2 is not
-16. (canceled)
-22. (canceled)
-44. (canceled)
(canceled)
-51. (canceled)
-69. (canceled)
A compound of Formula (II), or a pharmaceutically acceptable salt or deuterated form thereof:
- wherein,
- R1 is
- each R2 is independently H, F, Cl, Br, I or C1-C6 alkyl;
- and
- L is
- wherein the compound is not
-75. (canceled)
-148. (canceled)
-171. (canceled)
A compound of Formula (I-I):
- or a pharmaceutically acceptable salt or deuterated form thereof, wherein,
- R1 is
- R2 is
- X1, X2 and X3 are independently O, S, NR3 or CR3R4;
- each R3, R4 and R5 is independently H, F, Cl, Br, I or C1-C6 alkyl;
- each R6 is independently H or C1-C6 alkyl;
- each Y is independently O, S, CHR6 or NR6;
- m and m′ are each independently an integer from 0-3, and the total sum of m and m′ is ≤3;
- and
- L is
- provided that, the compound is not:
178-222. (canceled)
-328. (canceled)
Dependencies are inferred from the claim text.