Evolving random heteropolymers towards catalytically active materials
AssigneesMassachusetts Institute of Technology, The Regents of the University of California
InventorsAlfredo ALEXANDER-KATZ, Shayna HILBURG, Ting XU, Hao YU, Stefan Marco ERES, Philjun KANG
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Abstract
The present disclosure relates to using monomer-based heteropolymers to create random heteropolymers that act as biomimetic catalysts that can be evolved to mimic activities of different classes of natural enzymes. The random heteropolymers comprise a mixture of heteropolymer sequences wherein a portion of the heteropolymers comprise a catalytically active region similar to that of a naturally occurring enzyme active site.
Claims22
1-20. (canceled)
A biomimetic catalyst comprising a heteropolymer sequence;
- wherein the heteropolymer sequence comprises one or more heme molecules.
A composition of one or more of the biomimetic catalyst molecules comprising a heteropolymer sequence;
- wherein the heteropolymer sequence comprises one or more heme molecules.
A method of catalyzing a reaction comprising:
- (a) providing the biomimetic catalyst of claim 1;
- (b) incorporating a substrate;
- and
- (c) catalyzing a reaction.
A method of making a biomimetic catalyst comprising:
- (i) polymerizing monomers to form a heteropolymer sequence,
- wherein the monomers are methyl methacrylate (MMA), 2-ethylhexyl methacrylate (2-EHMA), oligo (ethylene glycol) methyl ether methacrylate (OEGMA), 3-sulfopropyl methacrylate potassium salt (SPMA), methacrylic acid N-hydroxysuccinimide ester (NHSMA), or a combination thereof;
- (ii) reacting the heteropolymer sequence with histamine;
- and
- (iii) contacting the heteropolymer sequence with heme.
Dependencies are inferred from the claim text.