# US 2026/0061162 A1 · Agent delivery catheter > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2026/0061162 A1 - Document ID: US20260061162A1 - Status: Published application - Kind: A1 - Application number: 19/314,447 - Filed: 2025-08-29 - Published: 2026-03-05 - Earliest claimed: 2024-08-30 - Assignees: Precision NeuroMed Inc. - Applicants: Precision NeuroMed Inc. - Inventors: Sandeep KUNWAR - Web page: https://patentgrep.com/patent/US20260061162A1 ## CPC - A61M 25/0026: {Multi-lumen catheters with stationary elements (catheter assemblies comprising a catheter in combination with a guide tube, sheath or sleeve A61M2025/0681; catheters comprising telescoping coaxial elements A61M2025/0175)} - A61M 25/003: {characterized by features relating to least one lumen located at the distal part of the catheter, e.g. filters, plugs or valves (catheter tips A61M25/0067)} - A61M 25/0032: {characterized by at least one unconventionally shaped lumen, e.g. polygons, ellipsoids, wedges or shapes comprising concave and convex parts} - A61M 25/0045: {multi-layered, e.g. coated (coating materials A61L29/08)} - A61M 25/0052: {Localized reinforcement, e.g. where only a specific part of the catheter is reinforced, for rapid exchange guidewire port} - A61M 25/0071: {Multiple separate lumens (multiple separate lumens throughout the catheter A61M25/0026)} - A61M 2025/0001: {for pressure measurement} - A61M 2025/0002: {with a pressure sensor at the distal end} - A61M 2025/0024: {Expandable catheters or sheaths} - A61M 2025/0031: {characterized by lumina for withdrawing or delivering, i.e. used for extracorporeal circuit treatment} - A61M 2025/0037: {characterized by lumina being arranged side-by-side} - A61M 2025/0042: {Microcatheters, cannula or the like having outside diameters around 1 mm or less} - A61M 2025/0063: {having means, e.g. stylets, mandrils, rods or wires to reinforce or adjust temporarily the stiffness, column strength or pushability of catheters which are already inserted into the human body} - A61M 2025/0166: {Sensors, electrodes or the like for guiding the catheter to a target zone, e.g. image guided or magnetically guided} - A61M 2205/0238: the material being a coating or protective layer - A61M 2205/3327: Measuring - A61M 2205/3331: Pressure; Flow - A61M 2205/3368: Temperature - A61M 2205/3375: Acoustical, e.g. ultrasonic, measuring means - A61M 2210/0693: Brain, cerebrum - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract A medical catheter includes a multi-lumen tube comprising a proximal end, a distal end, a first lumen, and a second lumen, the first lumen being sealed at the distal end. A retractable stylet of the catheter is carried in the first lumen of the multi-lumen tube. The stylet is adapted to stiffen the multi-lumen tube during a placement process and is movable relative to the multi-lumen tube. The first lumen being sealed at the distal end prevents the retractable stylet from protruding from the distal end of the multi-lumen tube. A capillary tube of the catheter is associated with the second lumen of the multi-lumen tube. The capillary tube has a distal tip for releasing an agent at the distal tip to a biological tissue. The distal tip of the capillary tube is an exposed portion of the capillary tube that protrudes beyond the distal end of the multi-lumen tube. ## Claims ### Claim 1 A medical catheter, comprising: a multi-lumen tube comprising a proximal end, a distal end, a first lumen, and a second lumen that is independent of the first lumen, the first lumen being sealed at the distal end; a retractable stylet carried in the first lumen of the multi-lumen tube, wherein the stylet is adapted to stiffen the multi-lumen tube during a placement process and is movable relative to the multi-lumen tube, wherein the first lumen being sealed at the distal end prevents the retractable stylet from protruding from the distal end of the multi-lumen tube; and a capillary tube of the second lumen of the multi-lumen tube, the capillary tube comprising a distal tip for releasing an agent at the distal tip to a biological tissue, wherein the distal tip of the capillary tube is an exposed portion of the capillary tube that protrudes beyond the distal end of the multi-lumen tube. ### Claim 2 (depends on 1) The medical catheter of claim 1, wherein the stylet is adapted to be retracted at least partially from the first lumen after the distal tip of the capillary tube is positioned at a desired position during the placement process to impart flexibility to the catheter during infusion. ### Claim 3 (depends on 1) The medical catheter of claim 1, wherein a diameter of the capillary tube is in a range of 100 micrometers to 2000 micrometers. ### Claim 4 (depends on 1) The medical catheter of claim 1, further comprising: a coupler connected to the distal end of the multi-lumen tube; and a reinforcement sleeve connected to the coupler, wherein the coupler has a conical shape and defines a step between the reinforcement sleeve having a first outer diameter and the multi-lumen tube having a second outer diameter that is greater than the first outer diameter. ### Claim 5 (depends on 4) The medical catheter of claim 4, wherein at least a portion of an external surface of the reinforcement sleeve is coated with a hydrophilic material. ### Claim 6 (depends on 4) The medical catheter of claim 4, wherein the reinforcement sleeve surrounds a portion of the capillary tube that protrudes beyond the distal end of the multi-lumen tube and the distal tip of the capillary tube extends through the reinforcement sleeve and protrudes from the reinforcement sleeve. ### Claim 7 (depends on 6) The medical catheter of claim 6, wherein reinforcement sleeve includes a tapered or stepped portion, the tapered or stepped portion defining a step between the reinforcement sleeve having the first outer diameter and the capillary tube having a third outer diameter that is less than the first outer diameter. ### Claim 8 (depends on 7) The medical catheter of claim 7, wherein a length of the capillary tube between the distal tip and a distal end of the reinforcement sleeve is in a range of 1 millimeter to 50 millimeters. ### Claim 9 (depends on 1) The medical catheter of claim 1, further comprising: a reinforcing member disposed in the multi-lumen tube at a position where the first lumen terminates, wherein the first lumen is sealed at a position where the reinforcing member is located. ### Claim 10 (depends on 9) The medical catheter of claim 9, wherein the reinforcing member is a cylindrical member that is adapted to stiffen a portion of the multi-lumen tube where the first lumen is sealed. ### Claim 11 (depends on 1) The medical catheter of claim 1, further comprising: a third lumen extending through the multi-lumen tube; and at least one sensor in the third lumen for detecting one or more of an agent reflux, an agent distribution, or a treatment effect. ### Claim 12 (depends on 11) The medical catheter of claim 11, wherein the at least one sensor includes: a pressure sensor configured to measure a pressure at one or more positions along the catheter; an electrical sensor configured to measure an electrical impedance; a temperature sensor configured to measure temperature at one or more positions along the catheter; a chemical sensor configured to detect a level of concentration of a chemical at one or more positions along the catheter; a positioning sensor to determine a location of the distal tip; or an ultrasound transducer to image tissue in a region outside the catheter. ### Claim 13 (depends on 1) The medical catheter of claim 1, further comprising: an expansile outer member downstream of the distal end of the multi-lumen tube, wherein the expansile outer member has a first outer diameter during a placing process and a second outer diameter during an agent delivery process, the second outer diameter being greater than the first outer diameter. ### Claim 14 (depends on 1) The medical catheter of claim 1, wherein the capillary tube extends continuously from a connector at the proximal end to the distal tip and passes through the second lumen of the multi-lumen tube. ### Claim 15 A catheter, comprising: a tube comprising a proximal end, a distal end, and a lumen, the lumen being sealed at the distal end; a retractable stylet carried in the lumen, wherein the retractable stylet is adapted to stiffen the tube during a placement process and is movable relative to the tube, wherein the lumen being sealed at the distal end prevents the retractable stylet from protruding from the distal end of the tube; a coupler connected to the distal end of the tube; and a capillary tube carried in the lumen, the capillary tube comprising a distal tip for releasing an agent at the distal tip to a biological tissue, wherein the distal tip of the capillary tube is an exposed portion of the capillary tube that protrudes beyond the distal end of the tube and a distal end of the coupler. ### Claim 16 A convection-enhanced delivery (CED) method, comprising: placing a distal tip of a catheter at a target location in the brain, the catheter comprising: a multi-lumen tube comprising a proximal end, a distal end, a first lumen, and a second lumen that is independent of the first lumen, the first lumen being sealed at the distal end; a retractable stylet carried in the first lumen of the multi-lumen tube, wherein the stylet is adapted to stiffen the multi-lumen tube during a placement process and is movable relative to the multi-lumen tube, wherein the first lumen being sealed at the distal end prevents the retractable stylet from protruding from the distal end of the multi-lumen tube; and a capillary tube of the second lumen of the multi-lumen tube, the capillary tube comprising the distal tip for releasing an agent at the distal tip to a biological tissue, wherein the distal tip of the capillary tube is an exposed portion of the capillary tube that protrudes beyond the distal end of the multi-lumen tube, removing the retractable stylet at least partially from the first lumen to impart flexibility to the catheter; and delivering an agent through the capillary tube to the target location. ### Claim 17 (depends on 16) The CED method of claim 16, further comprising: preventing reflux by creating a seal between brain tissue and an outer surface in a distal portion of the catheter. ### Claim 18 (depends on 16) The CED method of claim 16, wherein the catheter includes a sensor in a third lumen of the multi-lumen tube for detecting one or more of a drug reflux, a drug distribution, location, or a treatment effect, and wherein the CED method further comprises: detecting one or more properties during an agent delivery process using data obtained from the sensor; and controlling one or more parameters of the agent delivery process based on the detected one or more properties. ### Claim 19 (depends on 16) The CED method of claim 16, wherein a diameter of the capillary tube is in a range of 100 micrometers to 2000 micrometers. ### Claim 20 (depends on 16) The CED method of claim 16, wherein the catheter further comprises: a coupler connected to the distal end of the multi-lumen tube; and a reinforcement sleeve connected to the coupler, wherein the coupler has a conical shape and defines a step between the reinforcement sleeve having a first outer diameter and the multi-lumen tube having a second outer diameter that is greater than the first outer diameter, wherein an exterior surface of the reinforcement sleeve is coated with a hydrophilic material.