Mussel-inspired tissue adhesives and methods of use thereof
AssigneePurdue Research Foundation
InventorsJonathan Wilker, Julie Liu, Gudrun Schmidt, Aishwarya Menon
Life of this patent
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Abstract
Bioinspired adhesives comprising a macromolecule such as zein and one or more catechol- or gallol-containing compounds are provided. The adhesive can also comprise an iron crosslinker, an interfacial crosslinker, or both an iron crosslinker and an interfacial crosslinker. Methods of manufacturing and using the adhesive are also provided.
Claims34
An adhesive comprising:
- zein and one or more catechol- or gallol-containing compounds;
- or
- zein, one or more catechol- or gallol-containing compounds, and an interfacial crosslinker, an iron crosslinker, or both an interfacial crosslinker and an iron crosslinker.
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9-13. (canceled)
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A tissue sealant comprising a zein, tannic acid, and a solvent.
22-23. (canceled)
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A method of sealing a damaged tissue of a subject comprising applying an adhesive or a tissue sealant to a damaged tissue, wherein
- the adhesive comprises (a) zein and one or more catechol- or gallol-containing compounds, or (b) zein, one or more catechol- or gallol-containing compounds, and an interfacial crosslinker, an iron crosslinker, or both an interfacial crosslinker and an iron crosslinker;
- and
- the tissue sealant comprises a zein, tannic acid, and a solvent.
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A method of formulating an adhesive comprising:
- forming a first solution by combining zein, one or more catechol- or gallol-containing compounds, a solvent, and, optionally, an interfacial crosslinker, an iron crosslinker, or both an iron crosslinker and an interfacial crosslinker;
- adjusting a pH of the first solution to at or about 6-8 if needed;
- and
- curing the first solution to substantially remove the solvent therefrom.
54-56. (canceled)
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Dependencies are inferred from the claim text.