Correction of alzheimer's disease pathology
OwnerBhanu Pratap Jena, Won Jin Cho +1inventors
InventorsBHANU PRATAP JENA, WON JIN CHO, GUILLERMO G. MARMOL
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Abstract
Disclosed are compositions and/or methods of use of the compositions for patients with neuronal diseases such as AD, Parkinson's, Huntington's, multiple sclerosis, and ALS. In certain embodiments flavonoids alone, or in a pharmaceutical preparation, are administered through the nasal olfactory route. In certain embodiments the flavonoid is apigenin and the neural disease is Alzheimer's. In some embodiments a porosome complex is administered for reconstitution into a neural cell. In certain embodiments, a co-administered blood-brain barrier traversing peptide is configured as a mimic of a domain of ATP1A3 and/or Tubulin.
Claims10
A composition comprising:
- a flavonoid;
- a synthetic blood-brain barrier traversing peptide;
- a porosome or porosome protein;
- and,
- wherein the composition is pharmaceutically acceptable.
Dependencies are inferred from the claim text.