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US 2026/0061047 A1Published application
Newcastle Disease Virus with Improved Heat Resistance, and Newcastle Disease Virus Vaccine Comprising Same
AssigneeBiopoa, Inc.
InventorsSun-Hee Cho, Tae-Eun Kim
Life of this patent
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Abstract
The present specification provides: a Newcastle disease virus with improved heat resistance; a Newcastle disease vaccine comprising the virus; a polypeptide comprising an L protein in the virus; a polynucleotide encoding same; and a recombinant vector comprising the polynucleotide.
Claims12
A Newcastle disease virus comprising:
- NP, P, M and L proteins of a lentogenic Newcastle disease virus LaSota (AY845400);
- and
- F and HN proteins of a velogenic Newcastle disease virus KBNP-4152 (Accession No.:
- KCTC 10919BP),
- wherein the 115th amino acid of the F protein of the velogenic Newcastle disease virus is an amino acid selected from the group consisting of alanine, aspartic acid, phenylalanine, isoleucine, leucine, serine, threonine, valine, and tyrosine,
- wherein the 745th amino acid of the L protein is mutated to an amino acid other than alanine, and
- wherein the Newcastle disease virus exhibits improved thermostability compared to a Newcastle disease virus in which the 745th amino acid is alanine.
4 more elements
9-13. (canceled)
16-21. (canceled)
Dependencies are inferred from the claim text.