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US 2026/0061036 A1Published application
Retinal pigment epithelial (rpe) cell-directed peroxidase-based compositions, methods, and systems
AssigneeLysoclear, Inc.
InventorsKris Grohn, Kelsey Moody, Aaron Wolfe
Life of this patent
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Abstract
Various peroxidases are useful in treating subjects suffering from diseases associated with buildup of bisretinoids. The disclosed peroxidases may also be useful in activating prodrugs. The disclosed peroxidases may be administered as mature proteins or as coding sequences, in the form of expression vectors (as one example viral vectors) or lipid nanoparticles.
Claims23
A therapeutic composition comprising:
- one or more protein having an amino acid sequence at least 80% identical to one of SEQ ID NOs:1-119.
A therapeutic composition comprising:
- one or more nucleic acid coding for a protein having an amino acid sequence at least 80% identical one of SEQ ID NOs:1-119.
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A therapeutic particle comprising:
- a nucleic acid coding for a protein having an amino acid sequence at least 80% identical to one of SEQ ID NOs:1-119.
Dependencies are inferred from the claim text.