Gamma-secretase inhibitors for use in the treatment of inherited epidermolysis bullosa
OwnerAngelo Giuseppe CONDORELLI, Giovanna ZAMBRUNO +3inventors
InventorsAngelo Giuseppe CONDORELLI, Giovanna ZAMBRUNO, May EL HACHEM, Daniele CASTIGLIA, Teresa ODORISIO
Life of this patent
Estimating the term…
Abstract
The present invention concerns gamma-secretase inhibitors for use in the treatment of inherited epidermolysis bullosa and/or fibrosis associated to inherited epidermolysis bullosa, in particular for use in the treatment of recessive dystrophic epidermolysis bullosa and recessive dystrophic epidermolysis bullosa-associated fibrosis.
Claims13
Gamma-secretase inhibitor for use in the treatment of inherited epidermolysis bullosa and/or a fibrosis associated to inherited epidermolysis bullosa.
Pharmaceutical composition comprising a gamma-secretase inhibitor, together with one or more excipients and/or adjuvants, for use in the treatment of inherited epidermolysis bullosa and/or a fibrosis associated to inherited epidermolysis bullosa.
Combination of a gamma-secretase inhibitor with a product chosen from the group consisting of anti-inflammatory drugs, losartan, Angiotensin (Ang)-(1-7) heptapeptide, Ang-(1-7)-based pharmaceutical products, such as TXA127 and oral formulation of the heptapeptide angiotensin-(1-7), topical hydrogel formulations containing thymosin beta-4 (Tβ4), such as RGN-137, gels containing dry extract from birch bark, and topical gels containing Decorin, for separate or sequential use in the treatment of inherited epidermolysis bullosa and/or a fibrosis associated to inherited epidermolysis bullosa.
Dependencies are inferred from the claim text.